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2021 4
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2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses.
Uemura K, Nobori H, Sato A, Toba S, Kusakabe S, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Orba Y, Matsuura Y, Hall WW, Sawa H, Kida H, Matsuda A, Maenaka K. Uemura K, et al. Among authors: ishii m. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2304139120. doi: 10.1073/pnas.2304139120. Epub 2023 Oct 13. Proc Natl Acad Sci U S A. 2023. PMID: 37831739 Free PMC article.
Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides.
Hosono Y, Uchida S, Shinkai M, Townsend CE, Kelly CN, Naylor MR, Lee HW, Kanamitsu K, Ishii M, Ueki R, Ueda T, Takeuchi K, Sugita M, Akiyama Y, Lokey SR, Morimoto J, Sando S. Hosono Y, et al. Among authors: ishii m. Nat Commun. 2023 Mar 17;14(1):1416. doi: 10.1038/s41467-023-36978-z. Nat Commun. 2023. PMID: 36932083 Free PMC article.
Structure, solubility, and permeability relationships in a diverse middle molecule library.
Miyachi H, Kanamitsu K, Ishii M, Watanabe E, Katsuyama A, Otsuguro S, Yakushiji F, Watanabe M, Matsui K, Sato Y, Shuto S, Tadokoro T, Kita S, Matsumaru T, Matsuda A, Hirose T, Iwatsuki M, Shigeta Y, Nagano T, Kojima H, Ichikawa S, Sunazuka T, Maenaka K. Miyachi H, et al. Among authors: ishii m. Bioorg Med Chem Lett. 2021 Apr 1;37:127847. doi: 10.1016/j.bmcl.2021.127847. Epub 2021 Feb 9. Bioorg Med Chem Lett. 2021. PMID: 33571648
Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties.
Hirai K, Yamashita H, Tomoshige S, Mishima Y, Niwa T, Ohgane K, Ishii M, Kanamitsu K, Ikemi Y, Nakagawa S, Taguchi H, Sato S, Hashimoto Y, Ishikawa M. Hirai K, et al. Among authors: ishii m. ACS Med Chem Lett. 2022 Feb 16;13(3):396-402. doi: 10.1021/acsmedchemlett.1c00500. eCollection 2022 Mar 10. ACS Med Chem Lett. 2022. PMID: 35300080 Free PMC article.