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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Klionsky DJ, et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
Juvenile idiopathic arthritis-associated genetic loci exhibit spatially constrained gene regulatory effects across multiple tissues and immune cell types.
Pudjihartono N, Ho D, Golovina E, Fadason T, Kempa-Liehr AW, O'Sullivan JM. Pudjihartono N, et al. J Autoimmun. 2023 Jul;138:103046. doi: 10.1016/j.jaut.2023.103046. Epub 2023 May 23. J Autoimmun. 2023. PMID: 37229810 Free article.
We found target genes involved in immune-related pathways such as antigen processing and presentation (e.g., ERAP2, HLA class I and II), the release of pro-inflammatory cytokines (e.g., LTBR, TYK2), proliferation and differentiation of specific immune cell types (e. …
We found target genes involved in immune-related pathways such as antigen processing and presentation (e.g., ERAP2, HLA class I and I …
4-Ethylphenol-fluxes, metabolism and excretion of a gut microbiome derived neuromodulator implicated in autism.
Day F, O'Sullivan J, Pook C. Day F, et al. Front Mol Biosci. 2023 Oct 12;10:1267754. doi: 10.3389/fmolb.2023.1267754. eCollection 2023. Front Mol Biosci. 2023. PMID: 37900921 Free PMC article. Review.
We argue that the penetrative ability of 4EP is dependent on its form at the BBB and its physicochemical similarity to endogenous metabolites with dedicated active transport mechanisms across the BBB. We conclude that future research should focus on physical (e.g., ingesti …
We argue that the penetrative ability of 4EP is dependent on its form at the BBB and its physicochemical similarity to endogenous metabolite …
De novo identification of complex traits associated with asthma.
Zaied RE, Fadason T, O'Sullivan JM. Zaied RE, et al. Front Immunol. 2023 Aug 23;14:1231492. doi: 10.3389/fimmu.2023.1231492. eCollection 2023. Front Immunol. 2023. PMID: 37680636 Free PMC article.
All identified traits were previously reported to be comorbid or associated (positively or negatively) with asthma (e.g., depressive symptoms and lung cancer), except 8 traits whose association with asthma is yet to be confirmed (e.g., reticulocyte count). ...
All identified traits were previously reported to be comorbid or associated (positively or negatively) with asthma (e.g., depressive …
The infant gut microbiome and cognitive development in malnutrition.
Shennon I, Wilson BC, Behling AH, Portlock T, Haque R, Forrester T, Nelson CA, O'Sullivan JM; M4EFaD consortium. Shennon I, et al. Clin Nutr. 2024 Apr 4;43(5):1181-1189. doi: 10.1016/j.clnu.2024.03.029. Online ahead of print. Clin Nutr. 2024. PMID: 38608404 Free article. Review.
We conclude that there is a need for assessment of cognition and the use of various tools that permit visualization of the brain anatomy and function (e.g., Magnetic resonance imaging (MRI), functional near-infrared spectroscopy (fNIRS), electroencephalogram (EEG)) to unde …
We conclude that there is a need for assessment of cognition and the use of various tools that permit visualization of the brain anatomy and …
Sensory optimisation of salt-reduced corned beef for different consumer segments.
Conroy PM, O'Sullivan MG, Hamill RM, Kerry JP. Conroy PM, et al. Meat Sci. 2019 Aug;154:1-10. doi: 10.1016/j.meatsci.2019.03.015. Epub 2019 Mar 21. Meat Sci. 2019. PMID: 30954793
All age cohorts, with the exception of the 65-74 age cohort, accepted corned beef samples possessing NaCl levels closest to the FSAI target (1.63 g/100 g). No major sensory differences were noted between samples with and without potassium lactate by the 65 age cohor …
All age cohorts, with the exception of the 65-74 age cohort, accepted corned beef samples possessing NaCl levels closest to the FSAI target …
Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR.
Leask M, Dowdle A, Salvesen H, Topless R, Fadason T, Wei W, Schierding W, Marsman J, Antony J, O'Sullivan JM, Merriman TR, Horsfield JA. Leask M, et al. Front Genet. 2019 Jan 21;9:733. doi: 10.3389/fgene.2018.00733. eCollection 2018. Front Genet. 2019. PMID: 30719032 Free PMC article.
Collectively, our results are consistent with serum urate variants mediating long-range transcriptional regulation of the lincRNAs LINC01229 and MAFTRR and urate relevant genes (e.g., SLC5A8 and EHHADH) in trans....
Collectively, our results are consistent with serum urate variants mediating long-range transcriptional regulation of the lincRNAs LINC01229 …
Measuring reliable change in cognition using the Edinburgh Cognitive and Behavioural ALS Screen (ECAS).
Crockford C, Newton J, Lonergan K, Madden C, Mays I, O'Sullivan M, Costello E, Pinto-Grau M, Vajda A, Heverin M, Pender N, Al-Chalabi A, Hardiman O, Abrahams S. Crockford C, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):65-73. doi: 10.1080/21678421.2017.1407794. Epub 2017 Dec 7. Amyotroph Lateral Scler Frontotemporal Degener. 2018. PMID: 29214872 Free PMC article.
Understanding the impact of SNPs associated with autism spectrum disorder on biological pathways in the human fetal and adult cortex.
Golovina E, Fadason T, Lints TJ, Walker C, Vickers MH, O'Sullivan JM. Golovina E, et al. Sci Rep. 2021 Aug 5;11(1):15867. doi: 10.1038/s41598-021-95447-z. Sci Rep. 2021. PMID: 34354167 Free PMC article.
These eQTLs were also linked to other psychiatric disorders (e.g. schizophrenia, ADHD, bipolar disorder). Functional annotation of ASD-associated eQTLs revealed that they are involved in diverse regulatory processes. ...
These eQTLs were also linked to other psychiatric disorders (e.g. schizophrenia, ADHD, bipolar disorder). Functional annotation of AS …
A period of 10 weeks of increased protein consumption does not alter faecal microbiota or volatile metabolites in healthy older men: a randomised controlled trial.
Mitchell SM, McKenzie EJ, Mitchell CJ, Milan AM, Zeng N, D'Souza RF, Ramzan F, Sharma P, Rettedal E, Knowles SO, Roy NC, Sjödin A, Wagner KH, O'Sullivan JM, Cameron-Smith D. Mitchell SM, et al. J Nutr Sci. 2020 Jul 3;9:e25. doi: 10.1017/jns.2020.15. eCollection 2020. J Nutr Sci. 2020. PMID: 32742642 Free PMC article. Clinical Trial.
Healthy males (742 (sd 36) years; n 28) were randomised to consume the RDA of protein (08 g protein/kg body weight per d) or 2RDA, for 10 weeks. Dietary protein was provided via whole foods rather than supplementation or fortification. ...
Healthy males (742 (sd 36) years; n 28) were randomised to consume the RDA of protein (08 g protein/kg body weight per d) or 2RDA, fo …
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