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Showing results for matthias stable
Your search for Matthias Stabe retrieved no results
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency.
Forny P, Bonilla X, Lamparter D, Shao W, Plessl T, Frei C, Bingisser A, Goetze S, van Drogen A, Harshman K, Pedrioli PGA, Howald C, Poms M, Traversi F, Bürer C, Cherkaoui S, Morscher RJ, Simmons L, Forny M, Xenarios I, Aebersold R, Zamboni N, Rätsch G, Dermitzakis ET, Wollscheid B, Baumgartner MR, Froese DS. Forny P, et al. Nat Metab. 2023 Jan;5(1):80-95. doi: 10.1038/s42255-022-00720-8. Epub 2023 Jan 26. Nat Metab. 2023. PMID: 36717752 Free PMC article.
The relevance of these disturbances is evidenced by multi-organ metabolomics of a hemizygous Mmut mouse model as well as through identification of physical interactions between MMUT and glutamine anaplerotic enzymes. Using stable-isotope tracing, we find that treatment wit …
The relevance of these disturbances is evidenced by multi-organ metabolomics of a hemizygous Mmut mouse model as well as through identificat …
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial.
Bartsch R, Berghoff AS, Furtner J, Marhold M, Bergen ES, Roider-Schur S, Starzer AM, Forstner H, Rottenmanner B, Dieckmann K, Bago-Horvath Z, Haslacher H, Widhalm G, Ilhan-Mutlu A, Minichsdorfer C, Fuereder T, Szekeres T, Oehler L, Gruenberger B, Singer CF, Weltermann A, Puhr R, Preusser M. Bartsch R, et al. Nat Med. 2022 Sep;28(9):1840-1847. doi: 10.1038/s41591-022-01935-8. Epub 2022 Aug 8. Nat Med. 2022. PMID: 35941372 Free PMC article. Clinical Trial.
Two patients (13.3%) had a complete intracranial response, nine (60%) had a partial intracranial response and three (20%) had stable disease as the best intracranial response, with a best overall intracranial response rate of 73.3% (95% confidential interval 48.1-89.1%), t …
Two patients (13.3%) had a complete intracranial response, nine (60%) had a partial intracranial response and three (20%) had stable …
Toxin⁻Antitoxin Systems in Bacillus subtilis.
Brantl S, Müller P. Brantl S, et al. Toxins (Basel). 2019 May 9;11(5):262. doi: 10.3390/toxins11050262. Toxins (Basel). 2019. PMID: 31075979 Free PMC article. Review.
Toxin-antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afterwards found to also be widespread in bacterial chromosomes. TA loci comprise two genes, one coding for a stable toxin whose overexpr …
Toxin-antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afte …
Genome maintenance meets mechanobiology.
Spegg V, Altmeyer M. Spegg V, et al. Chromosoma. 2024 Jan;133(1):15-36. doi: 10.1007/s00412-023-00807-5. Epub 2023 Aug 15. Chromosoma. 2024. PMID: 37581649 Free PMC article. Review.
Genome stability is key for healthy cells in healthy organisms, and deregulated maintenance of genome integrity is a hallmark of aging and of age-associated diseases including cancer and neurodegeneration. To maintain a stable genome, genome surveillance and repair pathway …
Genome stability is key for healthy cells in healthy organisms, and deregulated maintenance of genome integrity is a hallmark of aging and o …
Quantitative Comparison of Proteomes Using SILAC.
Deng J, Erdjument-Bromage H, Neubert TA. Deng J, et al. Curr Protoc Protein Sci. 2019 Feb;95(1):e74. doi: 10.1002/cpps.74. Epub 2018 Sep 20. Curr Protoc Protein Sci. 2019. PMID: 30238645 Free PMC article. Review.
Stable isotope labeling by amino acids in cell culture (SILAC) has become very popular as a quantitative proteomic method since it was firstly introduced by Matthias Mann's group in 2002. ...
Stable isotope labeling by amino acids in cell culture (SILAC) has become very popular as a quantitative proteomic method since it wa …
Physiological Functions of Intracellular Protein Degradation.
McShane E, Selbach M. McShane E, et al. Annu Rev Cell Dev Biol. 2022 Oct 6;38:241-262. doi: 10.1146/annurev-cellbio-120420-091943. Epub 2022 May 19. Annu Rev Cell Dev Biol. 2022. PMID: 35587265 Review.
While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular protein degradation is an active and highly regulated process: Lysosomal, proteasomal, and mitochondrial degradation systems were identifie …
While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular …
Prognosis of patients with hepatocellular carcinoma treated with immunotherapy - development and validation of the CRAFITY score.
Scheiner B, Pomej K, Kirstein MM, Hucke F, Finkelmeier F, Waidmann O, Himmelsbach V, Schulze K, von Felden J, Fründt TW, Stadler M, Heinzl H, Shmanko K, Spahn S, Radu P, Siebenhüner AR, Mertens JC, Rahbari NN, Kütting F, Waldschmidt DT, Ebert MP, Teufel A, De Dosso S, Pinato DJ, Pressiani T, Meischl T, Balcar L, Müller C, Mandorfer M, Reiberger T, Trauner M, Personeni N, Rimassa L, Bitzer M, Trojan J, Weinmann A, Wege H, Dufour JF, Peck-Radosavljevic M, Vogel A, Pinter M. Scheiner B, et al. J Hepatol. 2022 Feb;76(2):353-363. doi: 10.1016/j.jhep.2021.09.035. Epub 2021 Oct 12. J Hepatol. 2022. PMID: 34648895 Free article.
Additionally, best radiological response (complete response/partial response/stable disease/progressive disease) was significantly better in patients with lower CRAFITY score (CRAFITY-low: 9%/20%/52%/20% vs. ...
Additionally, best radiological response (complete response/partial response/stable disease/progressive disease) was significantly be …
The CUL4B-based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho-specific DCAFs.
Stier A, Gilberto S, Mohamed WI, Royall LN, Helenius J, Mikicic I, Sajic T, Beli P, Müller DJ, Jessberger S, Peter M. Stier A, et al. EMBO J. 2023 Sep 4;42(17):e112847. doi: 10.15252/embj.2022112847. Epub 2023 Jun 27. EMBO J. 2023. PMID: 37365982 Free PMC article.
Finally, a human forebrain organoid model demonstrated that CUL4B is required to develop stable ventricular structures that correlate with onset of forebrain differentiation. ...
Finally, a human forebrain organoid model demonstrated that CUL4B is required to develop stable ventricular structures that correlate …
Robustness during Aging-Molecular Biological and Physiological Aspects.
Barth E, Sieber P, Stark H, Schuster S. Barth E, et al. Cells. 2020 Aug 8;9(8):1862. doi: 10.3390/cells9081862. Cells. 2020. PMID: 32784503 Free PMC article. Review.
However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, including physiological and molecular biological features, such as the hematoc …
However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various …
Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants.
Vogt SB, Ley L, Erne L, Straumann I, Becker AM, Klaiber A, Holze F, Vandersmissen A, Mueller L, Duthaler U, Rudin D, Luethi D, Varghese N, Eckert A, Liechti ME. Vogt SB, et al. Transl Psychiatry. 2023 May 23;13(1):172. doi: 10.1038/s41398-023-02477-4. Transl Psychiatry. 2023. PMID: 37221177 Free PMC article. Clinical Trial.
After stopping the infusion, all drug effects rapidly decreased and completely subsided within 15 min, consistent with a short early plasma elimination half-life (t(1/2alpha)) of 5.0-5.8 min, followed by longer late elimination (t(1/2beta) = 14-16 min) after 15-20 min. Subjective …
After stopping the infusion, all drug effects rapidly decreased and completely subsided within 15 min, consistent with a short early plasma …
313 results