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Page 1
Bivalent inhibitors of protein kinases.
Crit Rev Biochem Mol Biol. 2014 Mar-Apr;49(2):102-15. doi: 10.3109/10409238.2013.875513. Epub 2014 Feb 25.
Crit Rev Biochem Mol Biol. 2014.
PMID: 24564382
Free PMC article.
Review.
Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha-Mutant Endometrial Cancer.
Blanchard Z, Rush CM, Arnesen S, Vahrenkamp JM, Rodriguez AC, Jarboe EA, Brown C, Chang MEK, Flory MR, Mohammed H, Modzelewska K, Lum DH, Gertz J.
Blanchard Z, et al. Among authors: chang mek.
Mol Cancer Res. 2023 Oct 2;21(10):1023-1036. doi: 10.1158/1541-7786.MCR-22-0848.
Mol Cancer Res. 2023.
PMID: 37363949
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Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano-bio interactions.
Ferdosi S, Tangeysh B, Brown TR, Everley PA, Figa M, McLean M, Elgierari EM, Zhao X, Garcia VJ, Wang T, Chang MEK, Riedesel K, Chu J, Mahoney M, Xia H, O'Brien ES, Stolarczyk C, Harris D, Platt TL, Ma P, Goldberg M, Langer R, Flory MR, Benz R, Tao W, Cuevas JC, Batzoglou S, Blume JE, Siddiqui A, Hornburg D, Farokhzad OC.
Ferdosi S, et al. Among authors: chang mek.
Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2106053119. doi: 10.1073/pnas.2106053119. Epub 2022 Mar 11.
Proc Natl Acad Sci U S A. 2022.
PMID: 35275789
Free PMC article.
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ERG-Mediated Coregulator Complex Formation Maintains Androgen Receptor Signaling in Prostate Cancer.
Shah N, Kesten N, Font-Tello A, Chang MEK, Vadhi R, Lim K, Flory MR, Cejas P, Mohammed H, Long HW, Brown M.
Shah N, et al. Among authors: chang mek.
Cancer Res. 2020 Nov 1;80(21):4612-4619. doi: 10.1158/0008-5472.CAN-20-2044. Epub 2020 Sep 15.
Cancer Res. 2020.
PMID: 32934023
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Development of 2-(5,6,7-Trifluoro-1H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer.
Leblanc E, Ban F, Cavga AD, Lawn S, Huang CF, Mohan S, Chang MEK, Flory MR, Ghaidi F, Lingadahalli S, Chen G, Yu IPL, Morin H, Lallous N, Gleave ME, Mohammed H, Young RN, Rennie PS, Lack NA, Cherkasov A.
Leblanc E, et al. Among authors: chang mek.
J Med Chem. 2021 Oct 28;64(20):14968-14982. doi: 10.1021/acs.jmedchem.1c00681. Epub 2021 Oct 18.
J Med Chem. 2021.
PMID: 34661404
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Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer.
Ban F, Leblanc E, Cavga AD, Huang CF, Flory MR, Zhang F, Chang MEK, Morin H, Lallous N, Singh K, Gleave ME, Mohammed H, Rennie PS, Lack NA, Cherkasov A.
Ban F, et al. Among authors: chang mek.
Cancers (Basel). 2021 Jul 12;13(14):3488. doi: 10.3390/cancers13143488.
Cancers (Basel). 2021.
PMID: 34298700
Free PMC article.
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Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity.
Gower CM, Thomas JR, Harrington E, Murphy J, Chang ME, Cornella-Taracido I, Jain RK, Schirle M, Maly DJ.
Gower CM, et al. Among authors: chang me.
ACS Chem Biol. 2016 Jan 15;11(1):121-31. doi: 10.1021/acschembio.5b00847. Epub 2015 Nov 6.
ACS Chem Biol. 2016.
PMID: 26505072
Free PMC article.
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