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Page 1
Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation.
Cristancho Ortiz CJ, de Freitas Silva M, Pruccoli L, Fonseca Nadur N, de Azevedo LL, Kümmerle AE, Guedes IA, Dardenne LE, Leomil Coelho LF, Guimarães MJ, da Silva FMR, Castro N, Gontijo VS, Rojas VCT, de Oliveira MK, Vilela FC, Giusti-Paiva A, Barbosa G, Lima LM, Pinheiro GB, Veras LG, Mortari MR, Tarozzi A, Viegas C Jr. Cristancho Ortiz CJ, et al. Among authors: de freitas silva m. RSC Med Chem. 2022 Mar 17;13(5):568-584. doi: 10.1039/d1md00374g. eCollection 2022 May 25. RSC Med Chem. 2022. PMID: 35694691 Free PMC article.
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease.
Macedo Vaz S, de Freitas Silva M, Dos Reis Rosa Franco G, Jorge R Guimarães M, Motta R da Silva F, Gonçalves Castro N, Alvim Guedes I, Dardenne LE, Amaral Alves M, Garrett da Costa R, Beserra Pinheiro G, Germino Veras L, Renata Mortari M, Pruccoli L, Tarozzi A, Viegas C Jr. Macedo Vaz S, et al. Among authors: de freitas silva m. Bioorg Med Chem. 2022 Oct 1;71:116952. doi: 10.1016/j.bmc.2022.116952. Epub 2022 Aug 1. Bioorg Med Chem. 2022. PMID: 35930852
A synthetic resveratrol-curcumin hybrid derivative exhibits chemopreventive effects on colon pre-neoplastic lesions by targeting Wnt/β-catenin signaling, anti-inflammatory and antioxidant pathways.
Baptistella MM, Assunção RRS, Sales de Oliveira C, Siqueira AP, Gonçalves Dos Santos E, de Freitas Silva M, Lima ETF, Caixeta ES, Novaes RD, Ferreira EB, Ionta M, Viegas C Jr, Francielli de Oliveira P. Baptistella MM, et al. Among authors: de freitas silva m. J Pharm Pharmacol. 2023 Oct 24:rgad077. doi: 10.1093/jpp/rgad077. Online ahead of print. J Pharm Pharmacol. 2023. PMID: 37874746
11 results