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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 1
2013 1
2014 6
2015 3
2016 2
2017 3
2018 1
2019 2
2020 1
2021 2
2023 1
2024 0

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17 results

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Page 1
Deubiquitylating enzymes and drug discovery: emerging opportunities.
Harrigan JA, Jacq X, Martin NM, Jackson SP. Harrigan JA, et al. Nat Rev Drug Discov. 2018 Jan;17(1):57-78. doi: 10.1038/nrd.2017.152. Epub 2017 Sep 29. Nat Rev Drug Discov. 2018. PMID: 28959952 Free PMC article. Review.
More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin-proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors, first-generation deubiquitylating enzyme (DUB) inhibitors are now approaching clinical trials. Ho …
More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin-proteasome system and clinical approval of proteasome …
Genetics of Cushing's disease: an update.
Perez-Rivas LG, Reincke M. Perez-Rivas LG, et al. J Endocrinol Invest. 2016 Jan;39(1):29-35. doi: 10.1007/s40618-015-0353-0. Epub 2015 Jul 25. J Endocrinol Invest. 2016. PMID: 26208471 Review.
Using whole-exome sequencing, recurrent mutations have been reported in the gene coding for the ubiquitin-specific protease 8 (USP8), a protein with deubiquitinase (DUB) activity that modulates the lysosomal turnover of the EGF receptor (EGFR) and other membrane proteins. …
Using whole-exome sequencing, recurrent mutations have been reported in the gene coding for the ubiquitin-specific protease 8 (USP8), a prot …
High-Throughput Assay for Characterizing Rpn11 Deubiquitinase Activity.
Xie G, Dong KC, Worden EJ, Martin A. Xie G, et al. Methods Mol Biol. 2023;2591:79-100. doi: 10.1007/978-1-0716-2803-4_6. Methods Mol Biol. 2023. PMID: 36350544
Rpn11 is an essential metalloprotease responsible for the en bloc removal of ubiquitin chains from protein substrates that are targeted for degradation by the 26S proteasome. A unique feature of Rpn11 is that its deubiquitinase (DUB) activity is greatly stimulated by the m …
Rpn11 is an essential metalloprotease responsible for the en bloc removal of ubiquitin chains from protein substrates that are targeted for …
Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities.
Mielech AM, Chen Y, Mesecar AD, Baker SC. Mielech AM, et al. Virus Res. 2014 Dec 19;194:184-90. doi: 10.1016/j.virusres.2014.01.025. Epub 2014 Feb 7. Virus Res. 2014. PMID: 24512893 Free PMC article. Review.
Extension of these studies to other coronaviruses and arteriviruses led to the realization that viral protease/DUB activity is conserved in many family members. Overexpression studies revealed that viral protease/DUB activity can modulate or block activation of the …
Extension of these studies to other coronaviruses and arteriviruses led to the realization that viral protease/DUB activity is conser …
Bioconservatism, bioliberalism, and the wisdom of reflecting on repugnance.
Roache R, Clarke S. Roache R, et al. Monash Bioeth Rev. 2009 Mar;28(1):4.1-21. doi: 10.1007/BF03351306. Monash Bioeth Rev. 2009. PMID: 19839275 Review.
We consider the current debate between bioconservatives and their chief opponents--whom we dub bioliberals--about the moral acceptability of human enhancement and the policy implications of moral debates about enhancement. ...
We consider the current debate between bioconservatives and their chief opponents--whom we dub bioliberals--about the moral acceptabi …
How Computational Modeling Can Force Theory Building in Psychological Science.
Guest O, Martin AE. Guest O, et al. Perspect Psychol Sci. 2021 Jul;16(4):789-802. doi: 10.1177/1745691620970585. Epub 2021 Jan 22. Perspect Psychol Sci. 2021. PMID: 33482070
The inherent demands of computational modeling guide us toward better science by forcing us to conceptually analyze, specify, and formalize intuitions that otherwise remain unexamined-what we dub open theory. Constraining our inference process through modeling enables us t …
The inherent demands of computational modeling guide us toward better science by forcing us to conceptually analyze, specify, and formalize …
WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP.
Kim S, Woo SM, Min KJ, Seo SU, Lee TJ, Kubatka P, Kim DE, Kwon TK. Kim S, et al. Cancers (Basel). 2019 Mar 11;11(3):344. doi: 10.3390/cancers11030344. Cancers (Basel). 2019. PMID: 30862047 Free PMC article.
WP1130, a partially selective deubiquitinases (DUB) inhibitor, inhibits the deubiquitinating activities of USP5, USP9X, USP14, USP37, and UCHL1. ...
WP1130, a partially selective deubiquitinases (DUB) inhibitor, inhibits the deubiquitinating activities of USP5, USP9X, USP14, USP37, …
Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1).
Meyer T, Jahn N, Lindner S, Röhner L, Dolnik A, Weber D, Scheffold A, Köpff S, Paschka P, Gaidzik VI, Heckl D, Wiese S, Ebert BL, Döhner H, Bullinger L, Döhner K, Krönke J. Meyer T, et al. Leukemia. 2020 Feb;34(2):404-415. doi: 10.1038/s41375-019-0578-6. Epub 2019 Oct 1. Leukemia. 2020. PMID: 31576005 Free PMC article.
BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and DNA damage repair. ...
BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, int …
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.
Mielech AM, Kilianski A, Baez-Santos YM, Mesecar AD, Baker SC. Mielech AM, et al. Virology. 2014 Feb;450-451:64-70. doi: 10.1016/j.virol.2013.11.040. Epub 2013 Dec 22. Virology. 2014. PMID: 24503068 Free PMC article.
Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replicase polyprotein and deubiquitinating (DUB)/deISGylating activity, which is hypothesized to modify the innate immune response to infec …
Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replic …
17 results