Epigenetic dosage identifies two major and functionally distinct β cell subtypes.
Dror E, Fagnocchi L, Wegert V, Apostle S, Grimaldi B, Gruber T, Panzeri I, Heyne S, Höffler KD, Kreiner V, Ching R, Tsai-Hsiu Lu T, Semwal A, Johnson B, Senapati P, Lempradl A, Schones D, Imhof A, Shen H, Pospisilik JA.
Dror E, et al.
Cell Metab. 2023 May 2;35(5):821-836.e7. doi: 10.1016/j.cmet.2023.03.008. Epub 2023 Mar 21.
Cell Metab. 2023.
PMID: 36948185
Free article.
Here, we identify two major subtypes of pancreatic beta cells based on histone mark heterogeneity (beta(HI) and beta(LO)). beta(HI) cells exhibit 4-fold higher levels of H3K27me3, distinct chromatin organization and compaction, and a specific transcriptional pattern. beta( …
Here, we identify two major subtypes of pancreatic beta cells based on histone mark heterogeneity (beta(HI) and beta(LO)). beta(HI) c …