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2004 1
2005 1
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2022 3
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19 results

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Page 1
Histone H3.3 phosphorylation amplifies stimulation-induced transcription.
Armache A, Yang S, Martínez de Paz A, Robbins LE, Durmaz C, Cheong JQ, Ravishankar A, Daman AW, Ahimovic DJ, Klevorn T, Yue Y, Arslan T, Lin S, Panchenko T, Hrit J, Wang M, Thudium S, Garcia BA, Korb E, Armache KJ, Rothbart SB, Hake SB, Allis CD, Li H, Josefowicz SZ. Armache A, et al. Nature. 2020 Jul;583(7818):852-857. doi: 10.1038/s41586-020-2533-0. Epub 2020 Jul 22. Nature. 2020. PMID: 32699416 Free PMC article.
Here we show that this residue, H3.3S31, is phosphorylated (H3.3S31ph) in a stimulation-dependent manner along rapidly induced genes in mouse macrophages. This selective mark of stimulation-responsive genes directly engages the histone methyltransferase SETD2, a component …
Here we show that this residue, H3.3S31, is phosphorylated (H3.3S31ph) in a stimulation-dependent manner along rapidly induced genes in mous …
Epigenetic dosage identifies two major and functionally distinct β cell subtypes.
Dror E, Fagnocchi L, Wegert V, Apostle S, Grimaldi B, Gruber T, Panzeri I, Heyne S, Höffler KD, Kreiner V, Ching R, Tsai-Hsiu Lu T, Semwal A, Johnson B, Senapati P, Lempradl A, Schones D, Imhof A, Shen H, Pospisilik JA. Dror E, et al. Cell Metab. 2023 May 2;35(5):821-836.e7. doi: 10.1016/j.cmet.2023.03.008. Epub 2023 Mar 21. Cell Metab. 2023. PMID: 36948185 Free article.
Here, we identify two major subtypes of pancreatic beta cells based on histone mark heterogeneity (beta(HI) and beta(LO)). beta(HI) cells exhibit 4-fold higher levels of H3K27me3, distinct chromatin organization and compaction, and a specific transcriptional pattern. beta( …
Here, we identify two major subtypes of pancreatic beta cells based on histone mark heterogeneity (beta(HI) and beta(LO)). beta(HI) c …
Histone H3 proline 16 hydroxylation regulates mammalian gene expression.
Liu X, Wang J, Boyer JA, Gong W, Zhao S, Xie L, Wu Q, Zhang C, Jain K, Guo Y, Rodriguez J, Li M, Uryu H, Liao C, Hu L, Zhou J, Shi X, Tsai YH, Yan Q, Luo W, Chen X, Strahl BD, von Kriegsheim A, Zhang Q, Wang GG, Baldwin AS, Zhang Q. Liu X, et al. Nat Genet. 2022 Nov;54(11):1721-1735. doi: 10.1038/s41588-022-01212-x. Epub 2022 Nov 8. Nat Genet. 2022. PMID: 36347944 Free PMC article.
Specifically, our data demonstrate repression of the WNT pathway negative regulator DKK1 through the EGLN2-H3P16oh-KDM5A pathway to promote WNT/beta-catenin signaling in triple-negative breast cancer (TNBC). This study characterizes a regulatory mark in the histone code an …
Specifically, our data demonstrate repression of the WNT pathway negative regulator DKK1 through the EGLN2-H3P16oh-KDM5A pathway to promote …
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, Wong K, Pathuri S, Briand J, Steidel M, Chapman P, Groy A, Wiseman AK, McHugh CF, Campobasso N, Graves AP, Fairweather E, Werner T, Raoof A, Butlin RJ, Rueda L, Horton JR, Fosbenner DT, Zhang C, Handler JL, Muliaditan M, Mebrahtu M, Jaworski JP, McNulty DE, Burt C, Eberl HC, Taylor AN, Ho T, Merrihew S, Foley SW, Rutkowska A, Li M, Romeril SP, Goldberg K, Zhang X, Kershaw CS, Bantscheff M, Jurewicz AJ, Minthorn E, Grandi P, Patel M, Benowitz AB, Mohammad HP, Gilmartin AG, Prinjha RK, Ogilvie D, Carpenter C, Heerding D, Baylin SB, Jones PA, Cheng X, King BW, Luengo JI, Jordan AM, Waddell I, Kruger RG, McCabe MT. Pappalardi MB, et al. Nat Cancer. 2021 Oct;2(10):1002-1017. Epub 2021 Sep 27. Nat Cancer. 2021. PMID: 34790902 Free PMC article.
Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins.
Ren X, Zhou Y, Xue Z, Hao N, Li Y, Guo X, Wang D, Shi X, Li H. Ren X, et al. Nucleic Acids Res. 2021 Jan 11;49(1):114-126. doi: 10.1093/nar/gkaa1130. Nucleic Acids Res. 2021. PMID: 33290558 Free PMC article.
Lysine benzoylation (Kbz) on histones is a recently identified acylation mark associated with active transcription. However, it remains to be explored whether putative readers exist to recognize this epigenetic mark. ...
Lysine benzoylation (Kbz) on histones is a recently identified acylation mark associated with active transcription. However, it remai …
H3K9 methyltransferase EHMT2/G9a controls ERVK-driven noncanonical imprinted genes.
Zeng TB, Pierce N, Liao J, Szabó PE. Zeng TB, et al. Epigenomics. 2021 Aug;13(16):1299-1314. doi: 10.2217/epi-2021-0168. Epub 2021 Sep 14. Epigenomics. 2021. PMID: 34519223
Aim: Paternal allele-specific expression of noncanonical imprinted genes in the extraembryonic lineages depends on an H3K27me3-based imprint in the oocyte, which is not a lasting mark. We hypothesized that EHMT2, the main euchromatic H3K9 dimethyltransferase, also has a ro …
Aim: Paternal allele-specific expression of noncanonical imprinted genes in the extraembryonic lineages depends on an H3K27me3-based imprint …
Autosomal recessive LRP1-related syndrome featuring cardiopulmonary dysfunction, bone dysmorphology, and corneal clouding.
Mark PR, Murray SA, Yang T, Eby A, Lai A, Lu D, Zieba J, Rajasekaran S, VanSickle EA, Rossetti LZ, Guidugli L, Watkins K, Wright MS, Bupp CP, Prokop JW. Mark PR, et al. Cold Spring Harb Mol Case Stud. 2022 Oct 28;8(6):a006169. doi: 10.1101/mcs.a006169. Print 2022 Oct. Cold Spring Harb Mol Case Stud. 2022. PMID: 36307211 Free PMC article.
Extensive DNA methylome rearrangement during early lamprey embryogenesis.
Angeloni A, Fissette S, Kaya D, Hammond JM, Gamaarachchi H, Deveson IW, Klose RJ, Li W, Zhang X, Bogdanovic O. Angeloni A, et al. Nat Commun. 2024 Mar 4;15(1):1977. doi: 10.1038/s41467-024-46085-2. Nat Commun. 2024. PMID: 38438347 Free PMC article.
DNA methylation (5mC) is a repressive gene regulatory mark widespread in vertebrate genomes, yet the developmental dynamics in which 5mC patterns are established vary across species. ...
DNA methylation (5mC) is a repressive gene regulatory mark widespread in vertebrate genomes, yet the developmental dynamics in which …
Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
Zhang Y, Guo Y, Gough SM, Zhang J, Vann KR, Li K, Cai L, Shi X, Aplan PD, Wang GG, Kutateladze TG. Zhang Y, et al. Nat Commun. 2020 Jul 3;11(1):3339. doi: 10.1038/s41467-020-17098-4. Nat Commun. 2020. PMID: 32620764 Free PMC article.
Here, we report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and is inhibited by small molecule compounds, including disulfiram that directly targets the PHD finger of PHF23 (PHF23PHD). ...
Here, we report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and is inhibited by small molecule …
Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation.
Klein BJ, Jang SM, Lachance C, Mi W, Lyu J, Sakuraba S, Krajewski K, Wang WW, Sidoli S, Liu J, Zhang Y, Wang X, Warfield BM, Kueh AJ, Voss AK, Thomas T, Garcia BA, Liu WR, Strahl BD, Kono H, Li W, Shi X, Côté J, Kutateladze TG. Klein BJ, et al. Nat Commun. 2019 Oct 17;10(1):4724. doi: 10.1038/s41467-019-12551-5. Nat Commun. 2019. PMID: 31624313 Free PMC article.
Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and memory impairment, yet our understanding of this epigenetic mark remains insufficient. Here, we identify the native MORF complex as a histone H3K …
Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and memory impai …
19 results