Occurrence of thymic pathology in two families. Is familial screening justified?

Monaldi Arch Chest Dis. 2018 Sep 4;88(3):913. doi: 10.4081/monaldi.2018.913.

Abstract

The familial occurrence of thymic pathology, even though rare, is widely reported in the literature and mainly concerns cases of familial autoimmune myasthenia gravis. Other less frequent cases of familial occurrence of thymoma, thymic carcinoid and thymic hyperplasia have been described. It seems that the familial occurrence is poorly recorded and thus its prevalence is underestimated. We report two families whose members presented different forms of thymic pathology and discuss the necessity of screening programs in family members of patients presenting a thymic lesion.

Keywords: Familial; thymic carcinoma; thymic hyperplasia.; thymoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Carcinoma / diagnostic imaging*
  • Carcinoma / pathology
  • Carcinoma / surgery
  • Early Detection of Cancer
  • Family*
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Mass Screening
  • Middle Aged
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Thymoma / diagnostic imaging*
  • Thymoma / pathology
  • Thymoma / surgery
  • Thymus Hyperplasia / diagnostic imaging*
  • Thymus Hyperplasia / pathology
  • Thymus Hyperplasia / surgery
  • Thymus Neoplasms / diagnostic imaging*
  • Thymus Neoplasms / pathology
  • Thymus Neoplasms / surgery

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18