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2018 2
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Page 1
Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents.
Wójcik-Pszczoła K, Jankowska A, Ślusarczyk M, Jakieła B, Plutecka H, Pociecha K, Świerczek A, Popiół J, Koczurkiewicz-Adamczyk P, Wyska E, Pękala E, Gosens R, Chłoń-Rzepa G. Wójcik-Pszczoła K, et al. Among authors: slusarczyk m. Bioorg Chem. 2021 Dec;117:105409. doi: 10.1016/j.bioorg.2021.105409. Epub 2021 Oct 16. Bioorg Chem. 2021. PMID: 34749117 Free article.
Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation.
Chłoń-Rzepa G, Jankowska A, Ślusarczyk M, Świerczek A, Pociecha K, Wyska E, Bucki A, Gawalska A, Kołaczkowski M, Pawłowski M. Chłoń-Rzepa G, et al. Among authors: slusarczyk m. Eur J Med Chem. 2018 Feb 25;146:381-394. doi: 10.1016/j.ejmech.2018.01.068. Epub 2018 Feb 4. Eur J Med Chem. 2018. PMID: 29407965
A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling.
Wójcik-Pszczoła K, Chłoń-Rzepa G, Jankowska A, Ślusarczyk M, Ferdek PE, Kusiak AA, Świerczek A, Pociecha K, Koczurkiewicz-Adamczyk P, Wyska E, Pękala E, Gosens R. Wójcik-Pszczoła K, et al. Among authors: slusarczyk m. Int J Mol Sci. 2020 Jun 3;21(11):4008. doi: 10.3390/ijms21114008. Int J Mol Sci. 2020. PMID: 32503342 Free PMC article.
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
Chłoń-Rzepa G, Ślusarczyk M, Jankowska A, Gawalska A, Bucki A, Kołaczkowski M, Świerczek A, Pociecha K, Wyska E, Zygmunt M, Kazek G, Sałat K, Pawłowski M. Chłoń-Rzepa G, et al. Among authors: slusarczyk m. Eur J Med Chem. 2018 Oct 5;158:517-533. doi: 10.1016/j.ejmech.2018.09.021. Epub 2018 Sep 10. Eur J Med Chem. 2018. PMID: 30245393