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A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis.
Ostkamp P, Deffner M, Schulte-Mecklenbeck A, Wünsch C, Lu IN, Wu GF, Goelz S, De Jager PL, Kuhlmann T, Gross CC, Klotz L, Meyer Zu Hörste G, Wiendl H, Schneider-Hohendorf T, Schwab N. Ostkamp P, et al. Among authors: deffner m. Sci Transl Med. 2022 Nov 30;14(673):eadc9778. doi: 10.1126/scitranslmed.adc9778. Epub 2022 Nov 30. Sci Transl Med. 2022. PMID: 36449599
Enhanced pathogenicity of Th17 cells due to natalizumab treatment: Implications for MS disease rebound.
Janoschka C, Lindner M, Koppers N, Starost L, Liebmann M, Eschborn M, Schneider-Hohendorf T, Windener F, Schafflick D, Fleck AK, Koch K, Deffner M, Schwarze AS, Schulte-Mecklenbeck A, Metz I, Meuth SG, Gross CC, Meyer Zu Hörste G, Schwab N, Kuhlmann T, Wiendl H, Stoll M, Klotz L. Janoschka C, et al. Among authors: deffner m. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2209944120. doi: 10.1073/pnas.2209944120. Epub 2022 Dec 27. Proc Natl Acad Sci U S A. 2023. PMID: 36574650 Free PMC article.