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Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors.
Lefèvre L, Iacovoni JS, Martini H, Bellière J, Maggiorani D, Dutaur M, Marsal DJ, Decaunes P, Pizzinat N, Mialet-Perez J, Cussac D, Parini A, Douin-Echinard V. Lefèvre L, et al. Among authors: dutaur m. Cell Mol Life Sci. 2021 Apr;78(7):3485-3501. doi: 10.1007/s00018-020-03719-0. Epub 2020 Dec 12. Cell Mol Life Sci. 2021. PMID: 33313981 Free PMC article.
Local production of tenascin-C acts as a trigger for monocyte/macrophage recruitment that provokes cardiac dysfunction.
Abbadi D, Laroumanie F, Bizou M, Pozzo J, Daviaud D, Delage C, Calise D, Gaits-Iacovoni F, Dutaur M, Tortosa F, Renaud-Gabardos E, Douin-Echinard V, Prats AC, Roncalli J, Parini A, Pizzinat N. Abbadi D, et al. Among authors: dutaur m. Cardiovasc Res. 2018 Jan 1;114(1):123-137. doi: 10.1093/cvr/cvx221. Cardiovasc Res. 2018. PMID: 29136112
Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure.
Santin Y, Sicard P, Vigneron F, Guilbeau-Frugier C, Dutaur M, Lairez O, Couderc B, Manni D, Korolchuk VI, Lezoualc'h F, Parini A, Mialet-Perez J. Santin Y, et al. Among authors: dutaur m. Antioxid Redox Signal. 2016 Jul 1;25(1):10-27. doi: 10.1089/ars.2015.6522. Epub 2016 Apr 22. Antioxid Redox Signal. 2016. PMID: 26959532