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Page 1
Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression.
Pharmaceutics. 2021 Dec 7;13(12):2109. doi: 10.3390/pharmaceutics13122109.
Pharmaceutics. 2021.
PMID: 34959389
Free PMC article.
Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse.
Teich AF, Sharma E, Barnwell E, Zhang H, Staniszewski A, Utsuki T, Padmaraju V, Mazell C, Tzekou A, Sambamurti K, Arancio O, Maccecchini ML.
Teich AF, et al. Among authors: maccecchini ml.
Alzheimers Dement (N Y). 2018 Jan 18;4:37-45. doi: 10.1016/j.trci.2017.12.001. eCollection 2018.
Alzheimers Dement (N Y). 2018.
PMID: 29955650
Free PMC article.
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Translational inhibition of α-synuclein by Posiphen normalizes distal colon motility in transgenic Parkinson mice.
Kuo YM, Nwankwo EI, Nussbaum RL, Rogers J, Maccecchini ML.
Kuo YM, et al. Among authors: maccecchini ml.
Am J Neurodegener Dis. 2019 Feb 15;8(1):1-15. eCollection 2019.
Am J Neurodegener Dis. 2019.
PMID: 30906671
Free PMC article.
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The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen.
Rogers JT, Mikkilineni S, Cantuti-Castelvetri I, Smith DH, Huang X, Bandyopadhyay S, Cahill CM, Maccecchini ML, Lahiri DK, Greig NH.
Rogers JT, et al. Among authors: maccecchini ml.
J Neural Transm (Vienna). 2011 Mar;118(3):493-507. doi: 10.1007/s00702-010-0513-5. Epub 2011 Jan 8.
J Neural Transm (Vienna). 2011.
PMID: 21221670
Free PMC article.
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SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia.
Turner MS, Hamamoto DT, Hodges JS, Maccecchini ML, Simone DA.
Turner MS, et al. Among authors: maccecchini ml.
Brain Res. 2003 May 30;973(2):252-64. doi: 10.1016/s0006-8993(03)02525-3.
Brain Res. 2003.
PMID: 12738069
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Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans.
Maccecchini ML, Chang MY, Pan C, John V, Zetterberg H, Greig NH.
Maccecchini ML, et al.
J Neurol Neurosurg Psychiatry. 2012 Sep;83(9):894-902. doi: 10.1136/jnnp-2012-302589. Epub 2012 Jul 11.
J Neurol Neurosurg Psychiatry. 2012.
PMID: 22791904
Free PMC article.
Clinical Trial.
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