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Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells.
Rodenas MC, Peñas-Martínez J, Pardo-Sánchez I, Zaragoza-Huesca D, Ortega-Sabater C, Peña-García J, Espín S, Ricote G, Montenegro S, Ayala-De La Peña F, Luengo-Gil G, Nieto A, García-Molina F, Vicente V, Bernardi F, Lozano ML, Mulero V, Pérez-Sánchez H, Carmona-Bayonas A, Martínez-Martínez I. Rodenas MC, et al. Front Mol Biosci. 2023 May 19;10:1182925. doi: 10.3389/fmolb.2023.1182925. eCollection 2023. Front Mol Biosci. 2023. PMID: 37275957 Free PMC article.
Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors.
Zaragoza-Huesca D, Martínez-Cortés C, Banegas-Luna AJ, Pérez-Garrido A, Vegara-Meseguer JM, Peñas-Martínez J, Rodenas MC, Espín S, Pérez-Sánchez H, Martínez-Martínez I. Zaragoza-Huesca D, et al. Among authors: rodenas mc. Int J Mol Sci. 2022 Mar 3;23(5):2796. doi: 10.3390/ijms23052796. Int J Mol Sci. 2022. PMID: 35269938 Free PMC article.
Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells.
Peñas-Martínez J, Luengo-Gil G, Espín S, Bohdan N, Ortega-Sabater C, Ródenas MC, Zaragoza-Huesca D, López-Andreo MJ, Plasencia C, Vicente V, Carmona-Bayonas A, Martínez-Martínez I. Peñas-Martínez J, et al. Among authors: rodenas mc. Biomedicines. 2021 May 7;9(5):523. doi: 10.3390/biomedicines9050523. Biomedicines. 2021. PMID: 34067120 Free PMC article.
N-Glycosylation as a Tool to Study Antithrombin Secretion, Conformation, and Function.
Águila S, Noto R, Luengo-Gil G, Espín S, Bohdan N, de la Morena-Barrio ME, Peñas J, Rodenas MC, Vicente V, Corral J, Manno M, Martínez-Martínez I. Águila S, et al. Among authors: rodenas mc. Int J Mol Sci. 2021 Jan 6;22(2):516. doi: 10.3390/ijms22020516. Int J Mol Sci. 2021. PMID: 33419227 Free PMC article.
Suramin, a drug for the treatment of trypanosomiasis, reduces the prothrombotic and metastatic phenotypes of colorectal cancer cells by inhibiting hepsin.
Zaragoza-Huesca D, Rodenas MC, Peñas-Martínez J, Pardo-Sánchez I, Peña-García J, Espín S, Ricote G, Nieto A, García-Molina F, Vicente V, Lozano ML, Carmona-Bayonas A, Mulero V, Pérez-Sánchez H, Martínez-Martínez I. Zaragoza-Huesca D, et al. Among authors: rodenas mc. Biomed Pharmacother. 2023 Dec;168:115814. doi: 10.1016/j.biopha.2023.115814. Epub 2023 Oct 31. Biomed Pharmacother. 2023. PMID: 37918256 Free article.