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APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.
Farmer BC, Williams HC, Devanney NA, Piron MA, Nation GK, Carter DJ, Walsh AE, Khanal R, Young LEA, Kluemper JC, Hernandez G, Allenger EJ, Mooney R, Golden LR, Smith CT, Brandon JA, Gupta VA, Kern PA, Gentry MS, Morganti JM, Sun RC, Johnson LA. Farmer BC, et al. Among authors: piron ma. Mol Neurodegener. 2021 Sep 6;16(1):62. doi: 10.1186/s13024-021-00483-y. Mol Neurodegener. 2021. PMID: 34488832 Free PMC article.
APOE alters glucose flux through central carbon pathways in astrocytes.
Williams HC, Farmer BC, Piron MA, Walsh AE, Bruntz RC, Gentry MS, Sun RC, Johnson LA. Williams HC, et al. Among authors: piron ma. Neurobiol Dis. 2020 Mar;136:104742. doi: 10.1016/j.nbd.2020.104742. Epub 2020 Jan 11. Neurobiol Dis. 2020. PMID: 31931141 Free PMC article.