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The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis.
Unger C, Popescu R, Giessrigl B, Laimer D, Heider S, Seelinger M, Diaz R, Wallnöfer B, Egger G, Hassler M, Knöfler M, Saleh L, Sahin E, Grusch M, Fritzer-Szekeres M, Dolznig H, Frisch R, Kenner L, Kopp B, Krupitza G. Unger C, et al. Among authors: seelinger m. Int J Oncol. 2013 Jan;42(1):338-48. doi: 10.3892/ijo.2012.1690. Epub 2012 Nov 6. Int J Oncol. 2013. PMID: 23135783
An apolar extract of Critonia morifolia inhibits c-Myc, cyclin D1, Cdc25A, Cdc25B, Cdc25C and Akt and induces apoptosis.
Unger C, Popescu R, Giessrigl B, Rarova L, Herbacek I, Seelinger M, Diaz R, Wallnöfer B, Fritzer-Szekeres M, Szekeres T, Frisch R, Doležal K, Strnad M, De Martin R, Grusch M, Kopp B, Krupitza G. Unger C, et al. Among authors: seelinger m. Int J Oncol. 2012 Jun;40(6):2131-9. doi: 10.3892/ijo.2012.1412. Epub 2012 Mar 23. Int J Oncol. 2012. PMID: 22446629
Separation of anti-neoplastic activities by fractionation of a Pluchea odorata extract.
Bauer S, Singhuber J, Seelinger M, Unger C, Viola K, Vonach C, Giessrigl B, Madlener S, Stark N, Wallnofer B, Wagner KH, Fritzer-Szekeres M, Szekeres T, Diaz R, Tut F, Frisch R, Feistel B, Kopp B, Krupitza G, Popescu R. Bauer S, et al. Among authors: seelinger m. Front Biosci (Elite Ed). 2011 Jun 1;3(4):1326-36. doi: 10.2741/e336. Front Biosci (Elite Ed). 2011. PMID: 21622139 Free article.
Fractionation of an Extract of Pluchea odorata Separates a Property Indicative for the Induction of Cell Plasticity from One That Inhibits a Neoplastic Phenotype.
Seelinger M, Popescu R, Seephonkai P, Singhuber J, Giessrigl B, Unger C, Bauer S, Wagner KH, Fritzer-Szekeres M, Szekeres T, Diaz R, Tut FM, Frisch R, Feistel B, Kopp B, Krupitza G. Seelinger M, et al. Evid Based Complement Alternat Med. 2012;2012:701927. doi: 10.1155/2012/701927. Epub 2012 Mar 13. Evid Based Complement Alternat Med. 2012. PMID: 22474515 Free PMC article.