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Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease.
Macedo Vaz S, de Freitas Silva M, Dos Reis Rosa Franco G, Jorge R Guimarães M, Motta R da Silva F, Gonçalves Castro N, Alvim Guedes I, Dardenne LE, Amaral Alves M, Garrett da Costa R, Beserra Pinheiro G, Germino Veras L, Renata Mortari M, Pruccoli L, Tarozzi A, Viegas C Jr. Macedo Vaz S, et al. Among authors: jorge r guimaraes m. Bioorg Med Chem. 2022 Oct 1;71:116952. doi: 10.1016/j.bmc.2022.116952. Epub 2022 Aug 1. Bioorg Med Chem. 2022. PMID: 35930852
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease.
de Freitas Silva M, Tardelli Lima E, Pruccoli L, Castro NG, Guimarães MJR, M R da Silva F, Fonseca Nadur N, de Azevedo LL, Kümmerle AE, Guedes IA, Dardenne LE, Gontijo VS, Tarozzi A, Viegas C. de Freitas Silva M, et al. Among authors: guimaraes mjr. Molecules. 2020 Jul 10;25(14):3165. doi: 10.3390/molecules25143165. Molecules. 2020. PMID: 32664425 Free PMC article.
Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.
Lemes LFN, de Andrade Ramos G, de Oliveira AS, da Silva FMR, de Castro Couto G, da Silva Boni M, Guimarães MJR, Souza INO, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korábečný J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LAS. Lemes LFN, et al. Among authors: guimaraes mjr. Eur J Med Chem. 2016 Jan 27;108:687-700. doi: 10.1016/j.ejmech.2015.12.024. Epub 2015 Dec 17. Eur J Med Chem. 2016. PMID: 26735910