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Page 1
On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis.
Key FM, Khadka VD, Romo-González C, Blake KJ, Deng L, Lynn TC, Lee JC, Chiu IM, García-Romero MT, Lieberman TD. Key FM, et al. Cell Host Microbe. 2023 Apr 12;31(4):593-603.e7. doi: 10.1016/j.chom.2023.03.009. Cell Host Microbe. 2023. PMID: 37054679 Free PMC article.
Here, we show, by longitudinally tracking 23 children treated for AD, that S. aureus adapts via de novo mutations during colonization. Each patient's S. aureus population is dominated by a single lineage, with infrequent invasion by distant lineages. Mutation …
Here, we show, by longitudinally tracking 23 children treated for AD, that S. aureus adapts via de novo mutations during colonization …
Chromosome-level organization of the regulatory genome in the Drosophila nervous system.
Mohana G, Dorier J, Li X, Mouginot M, Smith RC, Malek H, Leleu M, Rodriguez D, Khadka J, Rosa P, Cousin P, Iseli C, Restrepo S, Guex N, McCabe BD, Jankowski A, Levine MS, Gambetta MC. Mohana G, et al. Cell. 2023 Aug 31;186(18):3826-3844.e26. doi: 10.1016/j.cell.2023.07.008. Epub 2023 Aug 2. Cell. 2023. PMID: 37536338
The Skin Microbiome of Patients With Atopic Dermatitis Normalizes Gradually During Treatment.
Khadka VD, Key FM, Romo-González C, Martínez-Gayosso A, Campos-Cabrera BL, Gerónimo-Gallegos A, Lynn TC, Durán-McKinster C, Coria-Jiménez R, Lieberman TD, García-Romero MT. Khadka VD, et al. Front Cell Infect Microbiol. 2021 Sep 24;11:720674. doi: 10.3389/fcimb.2021.720674. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34631601 Free PMC article. Clinical Trial.
BACKGROUND: Atopic dermatitis (AD) is characterized by an altered skin microbiome dominantly colonized by S. aureus. Standard treatment includes emollients, anti-inflammatory medications and antiseptics. ...As disease severity improved with treatment, the abundance of S …
BACKGROUND: Atopic dermatitis (AD) is characterized by an altered skin microbiome dominantly colonized by S. aureus. Standard treatme …
Remdesivir-Associated Pancreatitis.
Khadka S, Williams K, Solanki S. Khadka S, et al. Am J Ther. 2022 Jul 1;29(4):e444-e446. doi: 10.1097/MJT.0000000000001266. Am J Ther. 2022. PMID: 33590992
We report a case of acute pancreatitis that developed after four days of remdesivir therapy in a patient being treated for COVID-19. Despite improvement in patient's respiratory status, abdominal pain worsened and clinical signs and symptoms progressed to a diagnosis of ac …
We report a case of acute pancreatitis that developed after four days of remdesivir therapy in a patient being treated for COVID-19. Despite …
Early Childhood Oral Health and Nutrition in Urban and Rural Nepal.
Tsang C, Sokal-Gutierrez K, Patel P, Lewis B, Huang D, Ronsin K, Baral A, Bhatta A, Khadka N, Barkan H, Gurung S. Tsang C, et al. Int J Environ Res Public Health. 2019 Jul 10;16(14):2456. doi: 10.3390/ijerph16142456. Int J Environ Res Public Health. 2019. PMID: 31295932 Free PMC article.
Despite greater health knowledge and resources among urban mothers, urban children's increased access to junk food and frequency of consumption was associated with higher prevalence and severity of caries compared to rural children. ...
Despite greater health knowledge and resources among urban mothers, urban children's increased access to junk food and frequency of c …
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts.
Sterner RM, Sakemura R, Cox MJ, Yang N, Khadka RH, Forsman CL, Hansen MJ, Jin F, Ayasoufi K, Hefazi M, Schick KJ, Walters DK, Ahmed O, Chappell D, Sahmoud T, Durrant C, Nevala WK, Patnaik MM, Pease LR, Hedin KE, Kay NE, Johnson AJ, Kenderian SS. Sterner RM, et al. Blood. 2019 Feb 14;133(7):697-709. doi: 10.1182/blood-2018-10-881722. Epub 2018 Nov 21. Blood. 2019. PMID: 30463995 Free PMC article.
Poor oral hygiene, oral microorganisms and aspiration pneumonia risk in older people in residential aged care: a systematic review.
Khadka S, Khan S, King A, Goldberg LR, Crocombe L, Bettiol S. Khadka S, et al. Age Ageing. 2021 Jan 8;50(1):81-87. doi: 10.1093/ageing/afaa102. Age Ageing. 2021. PMID: 32677660
Isolation of Candida albicans, Staphylococcus aureus, methicillin-resistant S. aureus and Pseudomonas aeruginosa was related to mortality due to aspiration pneumonia. ...
Isolation of Candida albicans, Staphylococcus aureus, methicillin-resistant S. aureus and Pseudomonas aeruginosa was related to morta …
Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples.
Hoogman M, Muetzel R, Guimaraes JP, Shumskaya E, Mennes M, Zwiers MP, Jahanshad N, Sudre G, Wolfers T, Earl EA, Soliva Vila JC, Vives-Gilabert Y, Khadka S, Novotny SE, Hartman CA, Heslenfeld DJ, Schweren LJS, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avancini TM, Rosa PGP, Zanetti MV, Malpas CB, Kohls G, von Polier GG, Seitz J, Biederman J, Doyle AE, Dale AM, van Erp TGM, Epstein JN, Jernigan TL, Baur-Streubel R, Ziegler GC, Zierhut KC, Schrantee A, Høvik MF, Lundervold AJ, Kelly C, McCarthy H, Skokauskas N, O'Gorman Tuura RL, Calvo A, Lera-Miguel S, Nicolau R, Chantiluke KC, Christakou A, Vance A, Cercignani M, Gabel MC, Asherson P, Baumeister S, Brandeis D, Hohmann S, Bramati IE, Tovar-Moll F, Fallgatter AJ, Kardatzki B, Schwarz L, Anikin A, Baranov A, Gogberashvili T, Kapilushniy D, Solovieva A, El Marroun H, White T, Karkashadze G, Namazova-Baranova L, Ethofer T, Mattos P, Banaschewski T, Coghill D, Plessen KJ, Kuntsi J, Mehta MA, Paloyelis Y, Harrison NA, Bellgrove MA, Silk TJ, Cubillo AI, Rubia K, Lazaro L, Brem S, Walitza S, Frodl T, Zentis M, Castellanos FX, Yoncheva YN, Haavik J, Reneman L, Conzelmann A, Lesch KP, Pauli P, Reif A, Tamm L, Konrad K, Oberwelland Weiss E, Bus… See abstract for full author list ➔ Hoogman M, et al. Am J Psychiatry. 2019 Jul 1;176(7):531-542. doi: 10.1176/appi.ajp.2019.18091033. Epub 2019 Apr 24. Am J Psychiatry. 2019. PMID: 31014101 Free PMC article.
RESULTS: In the ENIGMA-ADHD sample, lower surface area values were found in children with ADHD, mainly in frontal, cingulate, and temporal regions; the largest significant effect was for total surface area (Cohen's d=-0.21). Fusiform gyrus and temporal pole cortical thickn …
RESULTS: In the ENIGMA-ADHD sample, lower surface area values were found in children with ADHD, mainly in frontal, cingulate, and temporal r …
Glucocorticoid regulation of cancer development and progression.
Khadka S, Druffner SR, Duncan BC, Busada JT. Khadka S, et al. Front Endocrinol (Lausanne). 2023 Apr 18;14:1161768. doi: 10.3389/fendo.2023.1161768. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37143725 Free PMC article. Review.
551 results