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Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19.
Gupta N, Settle L, Brown BR, Armaignac DL, Baram M, Perkins NE, Kaufman M, Melamed RR, Christie AB, Danesh VC, Denson JL, Cheruku SR, Boman K, Bansal V, Kumar VK, Walkey AJ, Domecq JP, Kashyap R, Aston CE; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Gupta N, et al. Crit Care Med. 2022 Oct 1;50(10):e744-e758. doi: 10.1097/CCM.0000000000005627. Epub 2022 Jul 27. Crit Care Med. 2022. PMID: 35894609 Free PMC article.
SUBJECTS: Adult hospitalized COVID-19 patients on antihypertensive agents (AHAs) prior to admission, admitted from March 31, 2020, to March 10, 2021. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Data were compared between three groups: patients on RAASIs only, other …
SUBJECTS: Adult hospitalized COVID-19 patients on antihypertensive agents (AHAs) prior to admission, admitted from March 31, 2020, to March …
Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19.
Denson JL, Gillet AS, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas IS, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer JG, Armaignac DL, Belden KA, Kaufman M, Heavner SF, Danesh VC, Cheruku SR, St Hill CA, Boman K, Deo N, Bansal V, Kumar VK, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Denson JL, et al. JAMA Netw Open. 2021 Dec 1;4(12):e2140568. doi: 10.1001/jamanetworkopen.2021.40568. JAMA Netw Open. 2021. PMID: 34935924 Free PMC article.
EXPOSURES: Exposures were SARS-CoV-2 infection, metabolic syndrome, obesity, prediabetes or diabetes, hypertension, and/or dyslipidemia. MAIN OUTCOMES AND MEASURES: The primary outcome was in-hospital mortality. ...
EXPOSURES: Exposures were SARS-CoV-2 infection, metabolic syndrome, obesity, prediabetes or diabetes, hypertension, and/or dyslipidemia. …
Environmental toxicants as extrinsic epigenetic factors for parkinsonism: studies employing transgenic C. elegans model.
Jadiya P, Nazir A. Jadiya P, et al. CNS Neurol Disord Drug Targets. 2012 Dec;11(8):976-83. doi: 10.2174/1871527311211080006. CNS Neurol Disord Drug Targets. 2012. PMID: 23244436 Review.
Amongst such diseases, neurodegenerative Parkinson's disease (PD) is a complex disorder in which genetics and exposure to toxins constitute the main determinants in the onset of the disease. Many studies have reported on a link between pesticide exposure and increased risk …
Amongst such diseases, neurodegenerative Parkinson's disease (PD) is a complex disorder in which genetics and exposure to toxins constitute …
Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial.
O'Brien MP, Forleo-Neto E, Sarkar N, Isa F, Hou P, Chan KC, Musser BJ, Bar KJ, Barnabas RV, Barouch DH, Cohen MS, Hurt CB, Burwen DR, Marovich MA, Brown ER, Heirman I, Davis JD, Turner KC, Ramesh D, Mahmood A, Hooper AT, Hamilton JD, Kim Y, Purcell LA, Baum A, Kyratsous CA, Krainson J, Perez-Perez R, Mohseni R, Kowal B, DiCioccio AT, Geba GP, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD, Weinreich DM; COVID-19 Phase 3 Prevention Trial Team. O'Brien MP, et al. JAMA. 2022 Feb 1;327(5):432-441. doi: 10.1001/jama.2021.24939. JAMA. 2022. PMID: 35029629 Free PMC article. Clinical Trial.
INTERVENTIONS: Individuals were randomized 1:1 to receive 1 dose of subcutaneous casirivimab and imdevimab, 1200 mg (600 mg of each; n = 158), or placebo (n = 156). MAIN OUTCOMES AND MEASURES: The primary end point was the proportion of seronegative participants who develo …
INTERVENTIONS: Individuals were randomized 1:1 to receive 1 dose of subcutaneous casirivimab and imdevimab, 1200 mg (600 mg of each; n = 158 …
The Effects of Opt-out vs Opt-in Tobacco Treatment on Engagement, Cessation, and Costs: A Randomized Clinical Trial.
Richter KP, Catley D, Gajewski BJ, Faseru B, Shireman TI, Zhang C, Scheuermann TS, Mussulman LM, Nazir N, Hutcheson T, Shergina E, Ellerbeck EF. Richter KP, et al. JAMA Intern Med. 2023 Apr 1;183(4):331-339. doi: 10.1001/jamainternmed.2022.7170. JAMA Intern Med. 2023. PMID: 36848129 Free PMC article. Clinical Trial.
Opt-in patients who were unwilling to quit received motivational counseling. MAIN OUTCOMES AND MEASURES: The main outcomes were biochemically verified abstinence and treatment uptake at 1 month after randomization. ...
Opt-in patients who were unwilling to quit received motivational counseling. MAIN OUTCOMES AND MEASURES: The main outcomes wer …
Trigonelline, a plant derived alkaloid prevents ultraviolet-B-induced oxidative DNA damage in primary human dermal fibroblasts and BALB/c mice via modulation of phosphoinositide 3-kinase-Akt-Nrf2 signalling axis.
Tanveer MA, Rashid H, Nazir LA, Archoo S, Shahid NH, Ragni G, Umar SA, Tasduq SA. Tanveer MA, et al. Exp Gerontol. 2023 Jan;171:112028. doi: 10.1016/j.exger.2022.112028. Epub 2022 Nov 13. Exp Gerontol. 2023. PMID: 36384201 Free article.
BACKGROUND: DNA is the main target for UV-B-irradiation-induced skin photodamage and accounts for 90 % of all the non-melanoma skin cancers. ...TG protects HDF cells and BALB/c mice from UV-B-induced DNA damage by regulating the expression profile of key protein markers of …
BACKGROUND: DNA is the main target for UV-B-irradiation-induced skin photodamage and accounts for 90 % of all the non-melanoma skin c …
Fault tolerance in computational grids: perspectives, challenges, and issues.
Haider S, Nazir B. Haider S, et al. Springerplus. 2016 Nov 18;5(1):1991. doi: 10.1186/s40064-016-3669-0. eCollection 2016. Springerplus. 2016. PMID: 27933247 Free PMC article. Review.
Fault tolerance is one of the most important issues faced by the computational grids. The main contribution of this survey is the creation of an extended classification of problems that incur in the computational grid environments. ...
Fault tolerance is one of the most important issues faced by the computational grids. The main contribution of this survey is the cre …
Investigation on the Phytochemical Composition, Antioxidant and Enzyme Inhibition Potential of Polygonum Plebeium R.Br: A Comprehensive Approach to Disclose New Nutraceutical and Functional Food Ingredients.
Saleem M, Shazmeen N, Nazir M, Riaz N, Zengin G, Ataullah HM, Qurat-Ul-Ain, Nisar F, Mukhtar M, Tousif MI. Saleem M, et al. Chem Biodivers. 2021 Dec;18(12):e2100706. doi: 10.1002/cbdv.202100706. Epub 2021 Nov 5. Chem Biodivers. 2021. PMID: 34636484
In Phosphomolybdenum activity assay, PP-H and PP-E showed nearly similar potential, however, PP-H was the most active (13.540.24 mgEDTAE/g extract) in metal chelating activity assay. PP-W was the stronger inhibitor (4.030.05 mgGALAE/g extract) of the enzyme AChE, wh …
In Phosphomolybdenum activity assay, PP-H and PP-E showed nearly similar potential, however, PP-H was the most active (13.540. …
Synthesis of β-Ketosulfone Derivatives As New Non-Cytotoxic Urease Inhibitors In Vitro.
Iqbal S, Khan A, Nazir R, Kiran S, Perveen S, Khan KM, Choudhary MI. Iqbal S, et al. Med Chem. 2020;16(2):244-255. doi: 10.2174/1573406415666190415163309. Med Chem. 2020. PMID: 30987574
Therefore, the discovery of urease inhibitors is an important area of medicinal chemistry research. OBJECTIVE: The main aim of the work was to identify novel urease inhibitors with no cytotoxicity. ...
Therefore, the discovery of urease inhibitors is an important area of medicinal chemistry research. OBJECTIVE: The main aim of the wo …
Warm Handoff Versus Fax Referral for Linking Hospitalized Smokers to Quitlines.
Richter KP, Faseru B, Shireman TI, Mussulman LM, Nazir N, Bush T, Scheuermann TS, Preacher KJ, Carlini BH, Magnusson B, Ellerbeck EF, Cramer C, Cook DJ, Martell MJ. Richter KP, et al. Am J Prev Med. 2016 Oct;51(4):587-96. doi: 10.1016/j.amepre.2016.04.006. Am J Prev Med. 2016. PMID: 27647059 Free PMC article. Clinical Trial.
Participants randomized to fax were referred on the day of hospital discharge. MAIN OUTCOME MEASURES: Outcomes at 6 months included quitline enrollment/adherence, medication use, biochemically verified cessation, and cost effectiveness. ...
Participants randomized to fax were referred on the day of hospital discharge. MAIN OUTCOME MEASURES: Outcomes at 6 months included q …
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