The use of guided bone regeneration to achieve a stable peri-implant bone foundation has been shown to be a highly predictable and successful treatment in dental implantology. A variety of methods have been described in the literature to obtain this objective, including the use of titanium mesh. In this report of two patient cases, CAD-designed and CAM-manufactured custom-made titanium meshes were used in the rebuilding of lost hard tissues. The case results showed the first patient presenting 4.1 mm vertical gain and a width of 8.7 mm and the second patient having 6.7 mm vertical gain and 10.8 mm width. Within the limits of these retrospective case reports, the two cases demonstrate that custom-made CAD/CAM titanium meshes are reliable and safe devices for bone augmentation, especially for vertical and horizontal combined defects. Soft-tissue handling for sufficient mesh coverage is the most critical step when using this technique. Mesh exposure had no influence on bone healing.