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Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles.
Hosen MR, Goody PR, Zietzer A, Xiang X, Niepmann ST, Sedaghat A, Tiyerili V, Chennupati R, Moore JB 4th, Boon RA, Uchida S, Sinning JM, Zimmer S, Latz E, Werner N, Nickenig G, Jansen F. Hosen MR, et al. Circulation. 2022 Dec 13;146(24):1836-1854. doi: 10.1161/CIRCULATIONAHA.122.060258. Epub 2022 Jul 8. Circulation. 2022. PMID: 35862223 Free article.
Several EV miRNAs (miR-122-5p, miR-26a, miR-192, miR-483-5p, miR-720, miR-885-5p, and miR-1274) were significantly deregulated in patients with aortic valve stenosis at day 7 after TAVR compared with the preprocedural levels in pat …
Several EV miRNAs (miR-122-5p, miR-26a, miR-192, miR-483-5p, miR-720, miR-885-5p, and miR-1 …
Atherosclerotic Conditions Promote the Packaging of Functional MicroRNA-92a-3p Into Endothelial Microvesicles.
Liu Y, Li Q, Hosen MR, Zietzer A, Flender A, Levermann P, Schmitz T, Frühwald D, Goody P, Nickenig G, Werner N, Jansen F. Liu Y, et al. Circ Res. 2019 Feb 15;124(4):575-587. doi: 10.1161/CIRCRESAHA.118.314010. Circ Res. 2019. PMID: 30582459
To validate the miR array results, 180 patients with angiographically excluded CAD (n=41), stable CAD (n=77), and acute coronary syndrome (n=62) were prospectively studied. Nine miRs involved in regulation of vascular performance-miR-126-3p, miR-222-3p …
To validate the miR array results, 180 patients with angiographically excluded CAD (n=41), stable CAD (n=77), and acute corona …
Myocardial microRNAs associated with reverse remodeling in human heart failure.
Sucharov CC, Kao DP, Port JD, Karimpour-Fard A, Quaife RA, Minobe W, Nunley K, Lowes BD, Gilbert EM, Bristow MR. Sucharov CC, et al. JCI Insight. 2017 Jan 26;2(2):e89169. doi: 10.1172/jci.insight.89169. JCI Insight. 2017. PMID: 28138556 Free PMC article.
RESULTS: At 3 months, 2 candidate miRs were selectively changed in Rs, decreases in miR-208a-3p and miR-591. PA revealed changes in miR-mRNA interactions predictive of decreased apoptosis and myocardial cell death. At 12 months, 5 miRs exhibited selective cha …
RESULTS: At 3 months, 2 candidate miRs were selectively changed in Rs, decreases in miR-208a-3p and miR-591. PA revealed chang …
Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia.
Welten SM, Bastiaansen AJ, de Jong RC, de Vries MR, Peters EA, Boonstra MC, Sheikh SP, La Monica N, Kandimalla ER, Quax PH, Nossent AY. Welten SM, et al. Circ Res. 2014 Sep 26;115(8):696-708. doi: 10.1161/CIRCRESAHA.114.304747. Epub 2014 Aug 1. Circ Res. 2014. PMID: 25085941
METHODS AND RESULTS: Gene silencing oligonucleotides (GSOs) were used to inhibit 4 14q32 microRNAs, miR-329, miR-487b, miR-494, and miR-495, 1 day before double femoral artery ligation. ...CONCLUSIONS: The 14q32 microRNA gene cluster is highly involved …
METHODS AND RESULTS: Gene silencing oligonucleotides (GSOs) were used to inhibit 4 14q32 microRNAs, miR-329, miR-487b, miR …
The Serum/Glucocorticoid-Regulated Kinase 1 Is Targeted by miR-19a in CD4+ T Cells.
Weidner J, Malmhäll C, Arabkari V, Barrett A, Boberg E, Ekerljung L, Rådinger M. Weidner J, et al. Cells. 2022 Dec 29;12(1):133. doi: 10.3390/cells12010133. Cells. 2022. PMID: 36611927 Free PMC article.
Moreover, we observed a negative correlation of miR-19a and SGK1 during early type 2 polarization of CD4+ naive human T cells. Thus, we suggest that miR-19a has a role in binding and regulating SGK1 transcript levels during T cell development....
Moreover, we observed a negative correlation of miR-19a and SGK1 during early type 2 polarization of CD4+ naive human T cells. Thus, …
MicroRNA expression profiling is a potential diagnostic tool for thyroid cancer.
Vriens MR, Weng J, Suh I, Huynh N, Guerrero MA, Shen WT, Duh QY, Clark OH, Kebebew E. Vriens MR, et al. Cancer. 2012 Jul 1;118(13):3426-32. doi: 10.1002/cncr.26587. Epub 2011 Oct 17. Cancer. 2012. PMID: 22006248 Free PMC article.
RESULTS: Ten miRNAs showed >5-fold expression difference between benign and malignant thyroid neoplasms on miRNA array analysis. Four of the 10 miRNAs were validated to be significantly differentially expressed between benign and malignant thyroid neoplasms by quantitat …
RESULTS: Ten miRNAs showed >5-fold expression difference between benign and malignant thyroid neoplasms on miRNA array analysis. F …
Differential Cardiac MicroRNA Expression Predicts the Clinical Course in Human Enterovirus Cardiomyopathy.
Kuehl U, Lassner D, Gast M, Stroux A, Rohde M, Siegismund C, Wang X, Escher F, Gross M, Skurk C, Tschoepe C, Loebel M, Scheibenbogen C, Schultheiss HP, Poller W. Kuehl U, et al. Circ Heart Fail. 2015 May;8(3):605-18. doi: 10.1161/CIRCHEARTFAILURE.114.001475. Epub 2015 Mar 11. Circ Heart Fail. 2015. PMID: 25761932
METHODS AND RESULTS: Transcriptome mapping of CVB3 cardiomyopathy patients revealed distinctive cardiac microRNA (miR) patterns associated with spontaneous virus clearance and recovery (CVB3-ELIM) versus virus persistence and progressive clinical deterioration (CVB3-PERS). …
METHODS AND RESULTS: Transcriptome mapping of CVB3 cardiomyopathy patients revealed distinctive cardiac microRNA (miR) patterns assoc …
Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury.
Rissin DM, López-Longarela B, Pernagallo S, Ilyine H, Vliegenthart ADB, Dear JW, Díaz-Mochón JJ, Duffy DC. Rissin DM, et al. PLoS One. 2017 Jul 5;12(7):e0179669. doi: 10.1371/journal.pone.0179669. eCollection 2017. PLoS One. 2017. PMID: 28678845 Free PMC article.
Single molecules of the biotin-labeled probe were then labeled with streptavidin-beta-galactosidase (SbetaG), the beads were resuspended in a fluorogenic enzyme substrate, loaded into an array of femtoliter wells, and sealed with oil. The array was imaged fluorescen …
Single molecules of the biotin-labeled probe were then labeled with streptavidin-beta-galactosidase (SbetaG), the beads were resuspended in …
iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function.
Rivers C, Idris J, Scott H, Rogers M, Lee YB, Gaunt J, Phylactou L, Curk T, Campbell C, Ule J, Norman M, Uney JB. Rivers C, et al. BMC Biol. 2015 Dec 22;13:111. doi: 10.1186/s12915-015-0220-7. BMC Biol. 2015. PMID: 26694817 Free PMC article.
For example, we found that the isoform-specific expression of neural cell adhesion molecule (NCAM1) and ASTN2 was influenced by SAFB1 and that the processing of miR-19a from the miR-17-92 cluster was regulated by SAFB1. These data suggest SAFB1 may influence alterna …
For example, we found that the isoform-specific expression of neural cell adhesion molecule (NCAM1) and ASTN2 was influenced by SAFB1 and th …
Natalizumab-induced POU2AF1/Spi-B upregulation: A possible route for PML development.
Meira M, Sievers C, Hoffmann F, Haghikia A, Rasenack M, Décard BF, Kuhle J, Derfuss T, Kappos L, Lindberg RL. Meira M, et al. Neurol Neuroimmunol Neuroinflamm. 2016 Mar 31;3(3):e223. doi: 10.1212/NXI.0000000000000223. eCollection 2016 Jun. Neurol Neuroimmunol Neuroinflamm. 2016. PMID: 27088119 Free PMC article.
The miRNA profiling was conducted in PBMCs from 5 untreated and 5 natalizumab-treated patients using low-density arrays followed by validation with single miRNAs assays in untreated and natalizumab-treated patients. ...In contrast, downregulation of POU2AF1/Spi-B expressio …
The miRNA profiling was conducted in PBMCs from 5 untreated and 5 natalizumab-treated patients using low-density arrays followed by v …