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Down-regulation of interleukin 6 receptor alpha chain in interleukin 6 transduced melanoma cells causes selective resistance to interleukin 6 but not to oncostatin M.
Silvani A, Ferrari G, Paonessa G, Toniatti C, Parmiani G, Colombo MP. Silvani A, et al. Cancer Res. 1995 May 15;55(10):2200-5. Cancer Res. 1995. PMID: 7743524
The cytokines interleukin 6 (IL-6) and oncostatin M are able to inhibit the growth of cell lines obtained from early but not advanced melanomas. ...These lines retained the previous oncostatin M sensitivity, suggesting that the alpha chain of IL-6 receptor (IL-6R al …
The cytokines interleukin 6 (IL-6) and oncostatin M are able to inhibit the growth of cell lines obtained from early but not advanced …
Phenotypic characterization of human colorectal cancer stem cells.
Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF. Dalerba P, et al. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63. doi: 10.1073/pnas.0703478104. Epub 2007 Jun 4. Proc Natl Acad Sci U S A. 2007. PMID: 17548814 Free PMC article.
An in vivo model to compare human leukocyte infiltration in carcinoma xenografts producing different chemokines.
Melani C, Pupa SM, Stoppacciaro A, Ménard S, Colnaghi MI, Parmiani G, Colombo MP. Melani C, et al. Int J Cancer. 1995 Sep 4;62(5):572-8. doi: 10.1002/ijc.2910620514. Int J Cancer. 1995. PMID: 7665228
Although both cell lines displayed a constitutive expression of granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage-CSF (GM-CSF), M-CSF, interleukin (IL-) 1 alpha and IL-8, only CALU-3 cell line expressed IL-10, RANTES (Regulated upon Activation, Normal T …
Although both cell lines displayed a constitutive expression of granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage-CSF (G …
HLA binding characteristics and generation of cytotoxic lymphocytes against peptides derived from oncogenic proteins.
Bertazzoli C, Marchesi E, Dermime S, Ravagnani F, Parmiani G, Gambacorti-Passerini C. Bertazzoli C, et al. Tumori. 1997 Sep-Oct;83(5):847-55. Tumori. 1997. PMID: 9428921
The stability of already formed complexed was somewhat different in the HLA-A3 and HLA-Cw*0702 system: both were more stable at 26 degrees C than at 37 degrees C but while the beta 2-m and FCS did not influence the stability of the HLA-A3/peptide complex, they seemed to ca …
The stability of already formed complexed was somewhat different in the HLA-A3 and HLA-Cw*0702 system: both were more stable at 26 degrees C …
Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm phase 2 trial.
Di Giacomo AM, Ascierto PA, Pilla L, Santinami M, Ferrucci PF, Giannarelli D, Marasco A, Rivoltini L, Simeone E, Nicoletti SV, Fonsatti E, Annesi D, Queirolo P, Testori A, Ridolfi R, Parmiani G, Maio M. Di Giacomo AM, et al. Lancet Oncol. 2012 Sep;13(9):879-86. doi: 10.1016/S1470-2045(12)70324-8. Epub 2012 Aug 13. Lancet Oncol. 2012. PMID: 22894884 Clinical Trial.
Participants received induction treatment of 10 mg/kg intravenous ipilimumab every 3 weeks to a total of four doses, and 100 mg/m(2) intravenous fotemustine weekly for 3 weeks and then every 3 weeks from week 9 to week 24. ...
Participants received induction treatment of 10 mg/kg intravenous ipilimumab every 3 weeks to a total of four doses, and 100 mg/m(2) …
Effect of prolonged subcutaneous administration of interleukin-2 on the circadian rhythms of cortisol and beta-endorphin in advanced small cell lung cancer patients.
Spinazzé S, Viviani S, Bidoli P, Rovelli F, Palmer P, Franks CR, Arienti F, Rivoltini L, Parmiani G. Spinazzé S, et al. Tumori. 1991 Dec 31;77(6):496-9. doi: 10.1177/030089169107700609. Tumori. 1991. PMID: 1666467
To investigate the problem, we evaluated cortisol circadian rhythms in 7 consecutive metastatic small cell lung cancer patients who received interleukin-2 subcutaneously for 4 weeks (daily dose: 6 x 10(6) x IU/m2). Venous blood samples were drawn at 8.00 a.m., 4.00 p.m …
To investigate the problem, we evaluated cortisol circadian rhythms in 7 consecutive metastatic small cell lung cancer patients who received …
Limited induction of tumor cross-reactive T cells without a measurable clinical benefit in early melanoma patients vaccinated with human leukocyte antigen class I-modified peptides.
Filipazzi P, Pilla L, Mariani L, Patuzzo R, Castelli C, Camisaschi C, Maurichi A, Cova A, Rigamonti G, Giardino F, Di Florio A, Asioli M, Frati P, Sovena G, Squarcina P, Maio M, Danielli R, Chiarion-Sileni V, Villa A, Lombardo C, Tragni G, Santinami M, Parmiani G, Rivoltini L. Filipazzi P, et al. Clin Cancer Res. 2012 Dec 1;18(23):6485-96. doi: 10.1158/1078-0432.CCR-12-1516. Epub 2012 Oct 2. Clin Cancer Res. 2012. PMID: 23032742 Clinical Trial.
The vaccine included four HLA-A*0201-restricted modified peptides (Melan-A/MART-1([27L]), gp100([210M]), NY-ESO-1([165V]), and Survivin([97M])) emulsified in Montanide ISA51 and injected subcutaneously in combination with cyclophosphamide (300 mg/m(2)) and low-dose IL-2 (3 …
The vaccine included four HLA-A*0201-restricted modified peptides (Melan-A/MART-1([27L]), gp100([210M]), NY-ESO-1([165V]), and Survivin([97M …
Vaccination of stage IV patients with allogeneic IL-4- or IL-2-gene-transduced melanoma cells generates functional antibodies against vaccinating and autologous melanoma cells.
Maio M, Fonsatti E, Lamaj E, Altomonte M, Cattarossi I, Santantonio C, Melani C, Belli F, Arienti F, Colombo MP, Parmiani G. Maio M, et al. Cancer Immunol Immunother. 2002 Mar;51(1):9-14. doi: 10.1007/s00262-001-0249-z. Epub 2001 Dec 18. Cancer Immunol Immunother. 2002. PMID: 11845255 Free PMC article. Clinical Trial.
Role of the alpha 5 beta 1 integrin receptor in the proliferative response of quiescent human melanoma cells to fibronectin.
Mortarini R, Gismondi A, Santoni A, Parmiani G, Anichini A. Mortarini R, et al. Cancer Res. 1992 Aug 15;52(16):4499-506. Cancer Res. 1992. PMID: 1386557
Mapping of FN regions responsible for the proliferative signal was performed by stimulating melanoma cells with different FN proteolytic fragments and indicated that a significant mitogenic signal was provided by the M(r) 120,000 alpha-chymotrypsin fragment containing the …
Mapping of FN regions responsible for the proliferative signal was performed by stimulating melanoma cells with different FN proteolytic fra …
Cross-reactions between tumor cells and allogeneic normal tissues. Inhibition of a syngeneic lymphoma outgrowth in H-2 and non-H-2 alloimmune BALB/c mice.
Parmiani G, Sensi ML, Carbone G, Colombo M, Pierotti M, Ballinari D, Hilgers J, Hilkens J. Parmiani G, et al. Int J Cancer. 1982 Mar 15;29(3):323-32. doi: 10.1002/ijc.2910290316. Int J Cancer. 1982. PMID: 7068280
Anti-YC8 effect was also induced by immunizing BALB/c recipients with a pool of five different allogeneic cell lines which included C3Hf, C57BL/6J (H-2b), N:NIH (H-2q), B10.M (H-2f), and DBA/2 lymphoid cells. No growth inhibition of other BALB/c lymphomas induced by Molone …
Anti-YC8 effect was also induced by immunizing BALB/c recipients with a pool of five different allogeneic cell lines which included C3Hf, C5 …
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