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Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models.
Kain BN, Tran BT, Luna PN, Cao R, Le DT, Florez MA, Maneix L, Toups JD, Morales-Mantilla DE, Koh S, Han H, Jaksik R, Huang Y, Catic A, Shaw CA, King KY. Kain BN, et al. iScience. 2023 Aug 9;26(9):107596. doi: 10.1016/j.isci.2023.107596. eCollection 2023 Sep 15. iScience. 2023. PMID: 37664586 Free PMC article.
Mice transplanted with influenza-trained HSPCs displayed enhanced immunity against M. avium challenge and vice versa, demonstrating cross protection against antigenically distinct pathogens. ...
Mice transplanted with influenza-trained HSPCs displayed enhanced immunity against M. avium challenge and vice versa, demonstrating c …
Decompression Sickness Risk Assessment and Awareness in General Aviation.
Harrison MF, Butler WP, Murad MH, Toups GN. Harrison MF, et al. Aerosp Med Hum Perform. 2021 Mar 1;92(3):138-145. doi: 10.3357/AMHP.5623.2021. Aerosp Med Hum Perform. 2021. PMID: 33754970
INTRODUCTION: Decompression sickness (DCS) can occur during unpressurized flight to altitudes >18,000 ft (FL180; 5486 m). To our knowledge, this has not been studied in general aviation (GA). ...Further study is warranted.Harrison MF, Butler WP, Murad MH, Toups G …
INTRODUCTION: Decompression sickness (DCS) can occur during unpressurized flight to altitudes >18,000 ft (FL180; 5486 m). To our k …
A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.
Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, Romashkan S, Williamson DA, Meydani SN, Villareal DT, Smith SR, Stein RI, Scott TM, Stewart TM, Saltzman E, Klein S, Bhapkar M, Martin CK, Gilhooly CH, Holloszy JO, Hadley EC, Roberts SB; CALERIE Study Group. Ravussin E, et al. J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1097-104. doi: 10.1093/gerona/glv057. Epub 2015 Jul 17. J Gerontol A Biol Sci Med Sci. 2015. PMID: 26187233 Free PMC article. Clinical Trial.
Outcomes were change from baseline resting metabolic rate adjusted for weight change ("RMR residual") and core temperature (primary); plasma triiodothyronine (T3) and tumor necrosis factor-alpha (secondary); and exploratory physiological and psychological measures. RESULTS: Body …
Outcomes were change from baseline resting metabolic rate adjusted for weight change ("RMR residual") and core temperature (primary); plasma …
Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.
Abud AA, Abi B, Acciarri R, Acero MA, Adames MR, Adamov G, Adamowski M, Adams D, Adinolfi M, Aduszkiewicz A, Aguilar J, Ahmad Z, Ahmed J, Aimard B, Ali-Mohammadzadeh B, Alion T, Allison K, Monsalve SA, AlRashed M, Alt C, Alton A, Alvarez R, Amedo P, Anderson J, Andreopoulos C, Andreotti M, Andrews M, Andrianala F, Andringa S, Anfimov N, Ankowski A, Antoniassi M, Antonova M, Antoshkin A, Antusch S, Aranda-Fernandez A, Arellano L, Arnold LO, Arroyave MA, Asaadi J, Asquith L, Aurisano A, Aushev V, Autiero D, Lara VA, Ayala-Torres M, Azfar F, Back A, Back H, Back JJ, Backhouse C, Bagaturia I, Bagby L, Balashov N, Balasubramanian S, Baldi P, Baller B, Bambah B, Barao F, Barenboim G, Alzas PB, Barker G, Barkhouse W, Barnes C, Barr G, Monarca JB, Barros A, Barros N, Barrow JL, Basharina-Freshville A, Bashyal A, Basque V, Batchelor C, Chagas EBD, Battat JBR, Battisti F, Bay F, Bazetto MCQ, Alba JLLB, Beacom JF, Bechetoille E, Behera B, Beigbeder C, Bellantoni L, Bellettini G, Bellini V, Beltramello O, Benekos N, Montiel CB, Neves FB, Berger J, Berkman S, Bernardini P, Berner RM, Bersani A, Bertolucci S, Betancourt M, Rodríguez AB, Bevan A, Bezawada Y, Bezerra TJC, Bhardwaj A, Bhatnagar V,… See abstract for full author list ➔ Abud AA, et al. Eur Phys J C Part Fields. 2022;82(7):618. doi: 10.1140/epjc/s10052-022-10549-w. Epub 2022 Jul 16. Eur Phys J C Part Fields. 2022. PMID: 35859696 Free PMC article.
DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6 6 6 m 3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platf …
DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE D …
Early Sex-Chromosome Evolution in the Diploid Dioecious Plant Mercurialis annua.
Veltsos P, Ridout KE, Toups MA, González-Martínez SC, Muyle A, Emery O, Rastas P, Hudzieczek V, Hobza R, Vyskot B, Marais GAB, Filatov DA, Pannell JR. Veltsos P, et al. Genetics. 2019 Jul;212(3):815-835. doi: 10.1534/genetics.119.302045. Epub 2019 May 21. Genetics. 2019. PMID: 31113811 Free PMC article.
Nevertheless, we found limited evidence for Y-chromosome degeneration in terms of gene loss and pseudogenization, and most X- and Y-linked genes appear to have diverged in the period subsequent to speciation between M. annua and its sister species M. huetii, which s …
Nevertheless, we found limited evidence for Y-chromosome degeneration in terms of gene loss and pseudogenization, and most X- and Y-linked g …
Dioecy and chromosomal sex determination are maintained through allopolyploid speciation in the plant genus Mercurialis.
Toups MA, Vicoso B, Pannell JR. Toups MA, et al. PLoS Genet. 2022 Jul 6;18(7):e1010226. doi: 10.1371/journal.pgen.1010226. eCollection 2022 Jul. PLoS Genet. 2022. PMID: 35793353 Free PMC article.
Here, we develop a bioinformatic pipeline using RNA-sequencing data from natural populations to demonstrate that the allopolyploid plant Mercurialis canariensis directly inherited its sex-determining region from one of its diploid progenitor species, M. annua, and likely r …
Here, we develop a bioinformatic pipeline using RNA-sequencing data from natural populations to demonstrate that the allopolyploid plant Mer …
A computational analysis of flanker interference in depression.
Dillon DG, Wiecki T, Pechtel P, Webb C, Goer F, Murray L, Trivedi M, Fava M, McGrath PJ, Weissman M, Parsey R, Kurian B, Adams P, Carmody T, Weyandt S, Shores-Wilson K, Toups M, McInnis M, Oquendo MA, Cusin C, Deldin P, Bruder G, Pizzagalli DA. Dillon DG, et al. Psychol Med. 2015 Aug;45(11):2333-44. doi: 10.1017/S0033291715000276. Epub 2015 Mar 2. Psychol Med. 2015. PMID: 25727375 Free PMC article.
22 results