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Page 1
Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes.
Gerstein HC, Sattar N, Rosenstock J, Ramasundarahettige C, Pratley R, Lopes RD, Lam CSP, Khurmi NS, Heenan L, Del Prato S, Dyal L, Branch K; AMPLITUDE-O Trial Investigators. Gerstein HC, et al. N Engl J Med. 2021 Sep 2;385(10):896-907. doi: 10.1056/NEJMoa2108269. Epub 2021 Jun 28. N Engl J Med. 2021. PMID: 34215025 Clinical Trial.
METHODS: In this randomized, placebo-controlled trial conducted at 344 sites across 28 countries, we evaluated efpeglenatide in participants with type 2 diabetes and either a history of cardiovascular disease or current kidney disease (defined as an estimated glomerular filtratio …
METHODS: In this randomized, placebo-controlled trial conducted at 344 sites across 28 countries, we evaluated efpeglenatide in participants …
First description of the Burmeister porpoise (Phocoena spinipinnis) electrocardiogram.
Dassis M, De León C, Díaz A, Faiella A, Olguin J, Saubidet A, Rodríguez DH, Castro EF. Dassis M, et al. J Exp Zool A Ecol Integr Physiol. 2022 Oct;337(8):795-801. doi: 10.1002/jez.2641. Epub 2022 Jul 14. J Exp Zool A Ecol Integr Physiol. 2022. PMID: 35833489
A total of three ECGs were made in one, wild juvenile female (body weight = 32.5 kg, Lt = 1.45 m), temporarily held in captivity for rehabilitation at Mar del Plata Aquarium (Argentina). ...The ECG characteristically displayed distinctly defined STs, with a T wave c …
A total of three ECGs were made in one, wild juvenile female (body weight = 32.5 kg, Lt = 1.45 m), temporarily held in captivity for …
Layer- and area-specificity of the adrenergic modulation of synaptic transmission in the rat neocortex.
Roychowdhury S, Zwierzchowski AN, Garcia-Oscos F, Olguin RC, Delgado RS, Atzori M. Roychowdhury S, et al. Neurochem Res. 2014 Dec;39(12):2377-84. doi: 10.1007/s11064-014-1440-x. Epub 2014 Sep 30. Neurochem Res. 2014. PMID: 25266551
To address these questions we used bath applications of NE (20 M) to determine its effects on pharmacologically isolated electrically-evoked 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propionic acid receptor (AMPAR)-mediated excitatory synaptic currents (eEPSCs), or gamm …
To address these questions we used bath applications of NE (20 M) to determine its effects on pharmacologically isolated electrically …
Doppler ultrasonographic assessment of maternal and fetal arteries during normal feline gestation.
Blanco PG, Rodríguez R, Olguín S, Rube A, Tórtora M, Gobello C. Blanco PG, et al. Anim Reprod Sci. 2014 Apr;146(1-2):63-9. doi: 10.1016/j.anireprosci.2014.02.003. Epub 2014 Feb 15. Anim Reprod Sci. 2014. PMID: 24602508
Color and pulsed-wave Doppler evaluations of uterine arteries were performed every 10 days (Day 0, 10, 20, 30, 40, 50, 60) from mating. Fetal Doppler and M-mode ultrasonography were performed to assess umbilical, fetal abdominal aorta, fetal renal, fetal internal carotid a …
Color and pulsed-wave Doppler evaluations of uterine arteries were performed every 10 days (Day 0, 10, 20, 30, 40, 50, 60) from mating. Feta …
Detection of flagellin by interaction with human recombinant TLR5 immobilized in liposomes.
Olguín Y, Villalobos P, Carrascosa LG, Young M, Valdez E, Lechuga L, Galindo R. Olguín Y, et al. Anal Bioanal Chem. 2013 Feb;405(4):1267-81. doi: 10.1007/s00216-012-6523-4. Epub 2012 Nov 22. Anal Bioanal Chem. 2013. PMID: 23180076
The results of the flagellin-affinity tests, expressed as an SPR kinetic rate constant ratio in the equilibrium equation K(D) = k(d)/k(a), showed values of 13.8 10(-9) and 7.73 10(-9) M for the TLR5-proteoliposomes and anti-flagellin antibodies, respectively, against S. ty …
The results of the flagellin-affinity tests, expressed as an SPR kinetic rate constant ratio in the equilibrium equation K(D) = k(d)/k(a), s …
Competitive lithium solvation of linear and cyclic carbonates from quantum chemistry.
Borodin O, Olguin M, Ganesh P, Kent PR, Allen JL, Henderson WA. Borodin O, et al. Phys Chem Chem Phys. 2016 Jan 7;18(1):164-75. doi: 10.1039/c5cp05121e. Epub 2015 Nov 25. Phys Chem Chem Phys. 2016. PMID: 26601903
A coordination preference for EC over DMC to a Li(+) was found at low salt concentrations, while a slightly higher preference for DMC over EC was found at high salt concentrations. Analysis of the relative binding energies of the (EC)n(DMC)m-Li(+) and (EC)n(DMC)m-Li …
A coordination preference for EC over DMC to a Li(+) was found at low salt concentrations, while a slightly higher preference for DMC over E …
Efficient catalytic promiscuity in an enzyme superfamily: an arylsulfatase shows a rate acceleration of 10(13) for phosphate monoester hydrolysis.
Olguin LF, Askew SE, O'Donoghue AC, Hollfelder F. Olguin LF, et al. J Am Chem Soc. 2008 Dec 10;130(49):16547-55. doi: 10.1021/ja8047943. J Am Chem Soc. 2008. PMID: 19554727
Besides hydrolyzing sulfate monoesters, this enzyme catalyzes the hydrolysis of phosphate monoesters with multiple turnovers (>90), a k(cat) value of 0.023 s(-1), a K(M) value of 29 microM, and a kcat/K(M) ratio of 790 M(-1) s(-1) at pH 8.0. This correspon …
Besides hydrolyzing sulfate monoesters, this enzyme catalyzes the hydrolysis of phosphate monoesters with multiple turnovers (>90), a k(c …
Prebiotic ingestion does not improve gastrointestinal barrier function in burn patients.
Olguin F, Araya M, Hirsch S, Brunser O, Ayala V, Rivera R, Gotteland M. Olguin F, et al. Burns. 2005 Jun;31(4):482-8. doi: 10.1016/j.burns.2004.11.017. Epub 2005 Feb 16. Burns. 2005. PMID: 15896512 Clinical Trial.
Gastrointestinal permeability to sucrose and lactulose/mannitol (L/M) was evaluated on days 1 (before treatment) 3, 7, 14 and 21. ...Healthy subjects had a basal sucrose excretion of 21.3 mg (14.0-32.5 mg) and a basal L/M ratio of 0.017% (0.009-0.022%). Sucrose excr …
Gastrointestinal permeability to sucrose and lactulose/mannitol (L/M) was evaluated on days 1 (before treatment) 3, 7, 14 and 21. ... …
Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal.
Olguin HC, Olwin BB. Olguin HC, et al. Dev Biol. 2004 Nov 15;275(2):375-88. doi: 10.1016/j.ydbio.2004.08.015. Dev Biol. 2004. PMID: 15501225 Free PMC article.
., Sabourin, L.A., Girgis-Gabardo, A., Mansouri, A., Gruss, P., Rudnicki, M.A., 2000. Pax7 is required for the specification of myogenic satellite cells. ...
., Sabourin, L.A., Girgis-Gabardo, A., Mansouri, A., Gruss, P., Rudnicki, M.A., 2000. Pax7 is required for the specification of myoge …
Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride.
Golicnik M, Olguin LF, Feng G, Baxter NJ, Waltho JP, Williams NH, Hollfelder F. Golicnik M, et al. J Am Chem Soc. 2009 Feb 4;131(4):1575-88. doi: 10.1021/ja806421f. J Am Chem Soc. 2009. PMID: 19132841
The overall stability constant for this complex is approximately 2 x 10(-16) M(5) and suggests an affinity of the MgF3(-) moiety to this transition-state analogue (TSA) of < or = 70 nM. ...
The overall stability constant for this complex is approximately 2 x 10(-16) M(5) and suggests an affinity of the MgF3(-) moiety to t …
16 results