Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors.
Abdallah AE, Mabrouk RR, Al Ward MMS, Eissa SI, Elkaeed EB, Mehany ABM, Abo-Saif MA, El-Feky OA, Alesawy MS, El-Zahabi MA.
Abdallah AE, et al.
J Enzyme Inhib Med Chem. 2022 Dec;37(1):573-591. doi: 10.1080/14756366.2021.2017911.
J Enzyme Inhib Med Chem. 2022.
PMID: 35012403
Free PMC article.
Compounds 15(a), 15(b), and 15(d) showed IC(50) from 17.39 to 47.10 M against human cancer cell lines; hepatocellular carcinoma (HepG2), prostate cancer (PC3), and breast cancer (MCF-7). Meanwhile, the first in terms of VEGFR-2 inhibition was compound 15(d) which came seco …
Compounds 15(a), 15(b), and 15(d) showed IC(50) from 17.39 to 47.10 M against human cancer cell lines; hepatocellular carcinoma (HepG …