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Novel 2-arylthiazolidin-4-one-thiazole hybrids with potent activity against Mycobacterium tuberculosis.
Othman DIA, Hamdi A, Abdel-Aziz MM, Elfeky SM. Othman DIA, et al. Bioorg Chem. 2022 Jul;124:105809. doi: 10.1016/j.bioorg.2022.105809. Epub 2022 Apr 14. Bioorg Chem. 2022. PMID: 35447406
Compounds T2 and T8 were capable of inhibiting M. tuberculosis InhA enzyme in-vitro with IC(50) = 1.3 0.61 M and 1.06 0.97 M, respectively. ...The 3D- QSAR study highlighted the relevance of substitution of phenyl group at position-2 of thiazolidin-4-one wher …
Compounds T2 and T8 were capable of inhibiting M. tuberculosis InhA enzyme in-vitro with IC(50) = 1.3 0.61 M and 1.06 0.97 …
Bioactive Azadirachta indica and Melia azedarach leaves extracts with anti-SARS-CoV-2 and antibacterial activities.
Hemdan BA, Mostafa A, Elbatanony MM, El-Feky AM, Paunova-Krasteva T, Stoitsova S, El-Liethy MA, El-Taweel GE, Abu Mraheil M. Hemdan BA, et al. PLoS One. 2023 Mar 8;18(3):e0282729. doi: 10.1371/journal.pone.0282729. eCollection 2023. PLoS One. 2023. PMID: 36888689 Free PMC article.
A. indica L. and M. azedarach L. leaves extracts could induce antibacterial activities against both Gram-negative and positive bacterial strains. The minimal inhibitory concentrations of A. indica L. and M. azedarach L. leaves extracts varied from 25 to 100 mg/mL wi …
A. indica L. and M. azedarach L. leaves extracts could induce antibacterial activities against both Gram-negative and positive bacter …
A novel sensor for the selective monitoring of trace ytterbium ions using an agarose-based optical membrane.
Amin AS, El-Feky HH, Hassan N. Amin AS, et al. RSC Adv. 2022 Sep 20;12(41):26620-26629. doi: 10.1039/d2ra03947h. eCollection 2022 Sep 16. RSC Adv. 2022. PMID: 36275166 Free PMC article.
The absorbance variation of the immobilized azastyrene film on agarose upon the addition of 1.5 10(-5) M aqueous solutions of La(3+), Y(3+), Al(3+), Sc(3+), Sm(3+), Eu(3+), Lu(3+), Fe(3+), Ce(3+), Cr(3+), S(2)O(3) (2-), Tb(3+), Mn(2+) and KIO(3) revealed substantial …
The absorbance variation of the immobilized azastyrene film on agarose upon the addition of 1.5 10(-5) M aqueous solutions of La(3+), …
Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors.
Abdallah AE, Mabrouk RR, Al Ward MMS, Eissa SI, Elkaeed EB, Mehany ABM, Abo-Saif MA, El-Feky OA, Alesawy MS, El-Zahabi MA. Abdallah AE, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):573-591. doi: 10.1080/14756366.2021.2017911. J Enzyme Inhib Med Chem. 2022. PMID: 35012403 Free PMC article.
Compounds 15(a), 15(b), and 15(d) showed IC(50) from 17.39 to 47.10 M against human cancer cell lines; hepatocellular carcinoma (HepG2), prostate cancer (PC3), and breast cancer (MCF-7). Meanwhile, the first in terms of VEGFR-2 inhibition was compound 15(d) which came seco …
Compounds 15(a), 15(b), and 15(d) showed IC(50) from 17.39 to 47.10 M against human cancer cell lines; hepatocellular carcinoma (HepG …
Cyclic fatigue resistance of M-Pro and RaCe Ni-Ti rotary endodontic instruments in artificial curved canals: a comparative in vitro study.
El Feky HM, Ezzat KM, Bedier MMA. El Feky HM, et al. Restor Dent Endod. 2019 Nov 7;44(4):e44. doi: 10.5395/rde.2019.44.e44. eCollection 2019 Nov. Restor Dent Endod. 2019. PMID: 31799171 Free PMC article.
MATERIALS AND METHODS: Thirty-six endodontic files with the same tip size and taper (size 25, 0.06 taper) were used. The samples were classified into 2 groups (n = 18): the M-Pro group (M-Pro IMD) and the RaCe group (FKG). A custom-made simulated canal model was fab …
MATERIALS AND METHODS: Thirty-six endodontic files with the same tip size and taper (size 25, 0.06 taper) were used. The samples were classi …
Sensitive optical thin film sensor based on incorporation of 2-(2'-hydroxynaphthylazo)-benzothiazole in a sol-gel matrix for detection of manganese(II) in environmental samples.
El-Feky HH, El-Bahy S, Amin AS. El-Feky HH, et al. Anal Biochem. 2022 Aug 15;651:114720. doi: 10.1016/j.ab.2022.114720. Epub 2022 May 6. Anal Biochem. 2022. PMID: 35533711
The offered sensor can be employed to evaluate Mn(II) ions within the range of 6.0 10(-8) - 1.5 10(-5) M with detection and quantification limits of 1.7 10(-8) and 5.5 10(-8) M, respectively. ...
The offered sensor can be employed to evaluate Mn(II) ions within the range of 6.0 10(-8) - 1.5 10(-5) M with detection and quantific …
A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S. mansoni infection.
Radwan A, El-Lakkany NM, William S, El-Feky GS, Al-Shorbagy MY, Saleh S, Botros S. Radwan A, et al. Parasit Vectors. 2019 Jun 17;12(1):304. doi: 10.1186/s13071-019-3563-z. Parasit Vectors. 2019. PMID: 31208446 Free PMC article.
A simple, cost-effective method was used to prepare SLN-PZQ. RESULTS: Compared to market PZQ (M-PZQ), SLN-PZQ was more bioavailable, as denoted by higher serum concentrations in both normal and infected mice where elevated K(a), AUC(0-24), C(max), and t(1/2e) with a decrea …
A simple, cost-effective method was used to prepare SLN-PZQ. RESULTS: Compared to market PZQ (M-PZQ), SLN-PZQ was more bioavailable, …
Superior sulcus tumor disguised as cervical radiculopathy with metastasis to brachial plexus.
Rizkalla J, Dauglas S, Nimmons S, El-Feky W, Syed I. Rizkalla J, et al. Proc (Bayl Univ Med Cent). 2019 Aug 20;32(4):582-583. doi: 10.1080/08998280.2019.1647737. eCollection 2019 Oct. Proc (Bayl Univ Med Cent). 2019. PMID: 31656428 Free PMC article.
Investigation revealed metastasis of a Pancoast tumor to the patient's brachial plexus. A year after initial diagnosis, the patient achieved full neurological function of his left arm. ...Thorough physical examination, imaging, and nerve conduction studies ultimately led t …
Investigation revealed metastasis of a Pancoast tumor to the patient's brachial plexus. A year after initial diagnosis, the patient a …
Quantification of silver in several samples using a new ionophore polymer membrane as an optical sensor.
El-Feky HH, Askar AM, Amin AS. El-Feky HH, et al. RSC Adv. 2021 Nov 1;11(56):35300-35310. doi: 10.1039/d1ra06660a. eCollection 2021 Oct 28. RSC Adv. 2021. PMID: 35493157 Free PMC article.
Under optimum conditions (i.e. pH 8.5), the proposed sensor displayed a linear response to Ag(+) over 4.8 10(-9) to 1.0 10(-5) M (0.8494-1698.7 mug L(-1)) with limits of detection and quantification of 1.5 10(-9) and 4.8 10(-9) M (0.2548 and 0.8494 mug L(-1)), respe …
Under optimum conditions (i.e. pH 8.5), the proposed sensor displayed a linear response to Ag(+) over 4.8 10(-9) to 1.0 10(-5) M (0.8 …