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Showing results for M. obaidullah
Your search for M. Obaydullah retrieved no results
Targeting VEGFR-2 by new quinoxaline derivatives: Design, synthesis, antiproliferative assay, apoptosis induction, and in silico studies.
Alsaif NA, Mahdy HA, Alanazi MM, Obaidullah AJ, Alkahtani HM, Al-Hossaini AM, Al-Mehizi AA, Elwan A, Taghour MS. Alsaif NA, et al. Arch Pharm (Weinheim). 2022 Feb;355(2):e2100359. doi: 10.1002/ardp.202100359. Epub 2021 Dec 3. Arch Pharm (Weinheim). 2022. PMID: 34862634
Compound 14a caused apoptosis in HepG2 cells and stopped the cell cycle at the G2/M phase. In HepG2 cells, it also increased the levels of the proteases caspase-3 and caspase-9, as well as the Bax/Bcl-2 ratio. ...
Compound 14a caused apoptosis in HepG2 cells and stopped the cell cycle at the G2/M phase. In HepG2 cells, it also increased the leve …
Antibacterial Efficacy of N-(4-methylpyridin-2-yl) Thiophene-2-Carboxamide Analogues against Extended-Spectrum-β-Lactamase Producing Clinical Strain of Escherichia coli ST 131.
Ahmad G, Khalid A, Qamar MU, Rasool N, Saadullah M, Bilal M, Bajaber MA, Obaidullah AJ, Alotaibi HF, Alotaibi JM. Ahmad G, et al. Molecules. 2023 Mar 31;28(7):3118. doi: 10.3390/molecules28073118. Molecules. 2023. PMID: 37049881 Free PMC article.
Multi-locus sequence typing of E. coli was conducted by identifying housekeeping genes, while ESBL phenotype detection was performed according to CLSI guidelines. Additionally, PCR was carried out to detect the blaCTX-M gene molecularly. Moreover, molecular docking studies …
Multi-locus sequence typing of E. coli was conducted by identifying housekeeping genes, while ESBL phenotype detection was performed accordi …
A Novel Green Micellar HPLC-UV Method for the Estimation of Vandetanib in Pure Form, Human Urine, Human Plasma and Human Liver Microsomes Matrices with Application to Metabolic Stability Evaluation.
Alanazi MM, Obaidullah AJ, Attwa MW. Alanazi MM, et al. Molecules. 2022 Dec 18;27(24):9038. doi: 10.3390/molecules27249038. Molecules. 2022. PMID: 36558172 Free PMC article.
This method was performed using a phenyl column (250 mm 4.6 mm id, 5 m particle size). A sodium dodecyl sulphate solution (0.05 M, pH 3.0 using 0.02 M orthophosphoric acid) containing 0.3% triethylamine and 10% n-butanol was used as a mobile phase and was pum …
This method was performed using a phenyl column (250 mm 4.6 mm id, 5 m particle size). A sodium dodecyl sulphate solution (0.05 M …
Discovery of Chromen-7-yl Furan-2-Carboxylate as a Potent and Selective Factor XIa Inhibitor.
Obaidullah AJ, Al-Horani RA. Obaidullah AJ, et al. Cardiovasc Hematol Agents Med Chem. 2017 Nov 8;15(1):40-48. doi: 10.2174/1871525715666170529093938. Cardiovasc Hematol Agents Med Chem. 2017. PMID: 28552062
RESULTS: This small molecule was found to inhibit FXIa with an IC50 value of 0.77 M. Coumarin 1 also displayed a moderate-to-high selectivity for FXIa inhibition over other coagulation, digestive, and fibrinolysis serine proteases. Coumarin 1 selectively doubled APTT of hu …
RESULTS: This small molecule was found to inhibit FXIa with an IC50 value of 0.77 M. Coumarin 1 also displayed a moderate-to-high sel …
Discovery of Novel Coumarin-Schiff Base Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Computational Studies.
Hasan AH, Abdulrahman FA, Obaidullah AJ, Alotaibi HF, Alanazi MM, Noamaan MA, Murugesan S, Amran SI, Bhat AR, Jamalis J. Hasan AH, et al. Pharmaceuticals (Basel). 2023 Jul 6;16(7):971. doi: 10.3390/ph16070971. Pharmaceuticals (Basel). 2023. PMID: 37513883 Free PMC article.
The IC(50) values ranged from 87.84 to 515.59 mug/mL; hybrids 13c and 13d with IC(50) values of 0.232 0.011 and 0.190 0.004 M, respectively, showed the most potent activity as acetylcholinesterase inhibitors (AChEIs). The reference drug, Galantamine, yielded an IC(50) of 1 …
The IC(50) values ranged from 87.84 to 515.59 mug/mL; hybrids 13c and 13d with IC(50) values of 0.232 0.011 and 0.190 0.004 M, respec …
New bis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer evaluation.
Alanazi MM, Mahdy HA, Alsaif NA, Obaidullah AJ, Alkahtani HM, Al-Mehizia AA, Alsubaie SM, Dahab MA, Eissa IH. Alanazi MM, et al. Bioorg Chem. 2021 Jul;112:104949. doi: 10.1016/j.bioorg.2021.104949. Epub 2021 Apr 30. Bioorg Chem. 2021. PMID: 34023640
The results exhibited that compounds 20b, 20e, 20h and20mshowed promising VEGFR-2 inhibitory activities with IC(50)values of 5.7, 6.7, 3.2, and 3.1 M, respectively. Moreover, these promising members exhibited the highest antiproliferative activities against the two cell li …
The results exhibited that compounds 20b, 20e, 20h and20mshowed promising VEGFR-2 inhibitory activities with IC(50)values of 5.7, 6.7, 3.2, …
Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies.
Alsaif NA, Taghour MS, Alanazi MM, Obaidullah AJ, Alanazi WA, Alasmari A, Albassam H, Dahab MA, Mahdy HA. Alsaif NA, et al. Bioorg Med Chem. 2021 Sep 15;46:116384. doi: 10.1016/j.bmc.2021.116384. Epub 2021 Aug 28. Bioorg Med Chem. 2021. PMID: 34479065
Compound 19a exhibited the highest activity towards both MCF-7 and HepG2 cell lines (IC(50) = 8.2 and 5.4 M, respectively), compared to sorafenib (IC(50) = 3.51 and 2.17 M, respectively). ...Furthermore, compound 19a disrupted the HepG2 cell cycle by arresting the G …
Compound 19a exhibited the highest activity towards both MCF-7 and HepG2 cell lines (IC(50) = 8.2 and 5.4 M, respectively), compared …
Detection of tumour infiltrating lymphocytes in CD3 and CD8 stained histopathological images using a two-phase deep CNN.
Zafar MM, Rauf Z, Sohail A, Khan AR, Obaidullah M, Khan SH, Lee YS, Khan A. Zafar MM, et al. Photodiagnosis Photodyn Ther. 2022 Mar;37:102676. doi: 10.1016/j.pdpdt.2021.102676. Epub 2021 Dec 8. Photodiagnosis Photodyn Ther. 2022. PMID: 34890783
The inference code is available at GitHub Repository https://github.com/m-mohsin-zafar/tdc-lc. RESULTS: The empirical evaluation on samples from LYSTO dataset shows that the proposed LSTAM-Net can learn variations in the images and precisely remove the hard negative stain …
The inference code is available at GitHub Repository https://github.com/m-mohsin-zafar/tdc-lc. RESULTS: The empirical evaluation on s …
19 results