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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2005 1
2007 1
2011 1
2016 1
2017 1
2018 5
2019 2
2020 4
2021 4
2022 3
2023 4
2024 0

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24 results

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Page 1
Cladamide: a new ceramide from the endophytic fungus Cladosporium cladosporioides.
Sallam A, El-Metwally M, Sabry MA, Elsbaey M. Sallam A, et al. Nat Prod Res. 2023 Apr;37(7):1082-1091. doi: 10.1080/14786419.2021.1986709. Epub 2021 Oct 8. Nat Prod Res. 2023. PMID: 34622719
Compound 3 showed the highest acetylcholine esterase inhibitory activity (IC(50) = 0.057 0.003 M), followed by compound 4 (IC(50) = 0.068 0.003 M) and compound 1 (IC(50) = 0.099 0.005 M) compared to donepezil, the positive control, (IC(50) = 0.044 0.002 M …
Compound 3 showed the highest acetylcholine esterase inhibitory activity (IC(50) = 0.057 0.003 M), followed by compound 4 (IC(50) = 0 …
Aurasperone A Inhibits SARS CoV-2 In Vitro: An Integrated In Vitro and In Silico Study.
ElNaggar MH, Abdelwahab GM, Kutkat O, GabAllah M, Ali MA, El-Metwally MEA, Sayed AM, Abdelmohsen UR, Khalil AT. ElNaggar MH, et al. Mar Drugs. 2022 Feb 28;20(3):179. doi: 10.3390/md20030179. Mar Drugs. 2022. PMID: 35323478 Free PMC article.
Aurasperone A (3) was found to inhibit SARS CoV-2 efficiently (IC(50) = 12.25 M) with comparable activity with the positive control remdesivir (IC(50) = 10.11 M). ...More potent anti-SARS CoV-2 M(pro) inhibitors can be developed according to our findings pres …
Aurasperone A (3) was found to inhibit SARS CoV-2 efficiently (IC(50) = 12.25 M) with comparable activity with the positive control r …
Terretonin O: a new meroterpenoid from Aspergillus terreus.
Hamed A, Abdel-Razek AS, Omran DA, El-Metwally MM, El-Hosari DG, Frese M, Soliman HSM, Sewald N, Shaaban M. Hamed A, et al. Nat Prod Res. 2020 Apr;34(7):965-974. doi: 10.1080/14786419.2018.1544977. Epub 2019 Jan 3. Nat Prod Res. 2020. PMID: 30602325
Terretonin O (1), a new meroterpenoid, was isolated individually from both methanolic extracts of thermophilic Aspergillus terreus TM8 and marine Aspergillus terreus LGO13. The recently reported terretonins M (2) and N (3) were further isolated from the fungus LGO13 along …
Terretonin O (1), a new meroterpenoid, was isolated individually from both methanolic extracts of thermophilic Aspergillus terreus TM8 and m …
New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies.
Gaber AA, Sobhy M, Turky A, Eldehna WM, El-Sebaey SA, El-Metwally SA, El-Naggar AM, Ibrahim IM, Elkaeed EB, Metwaly AM, Eissa IH. Gaber AA, et al. PLoS One. 2023 Jan 30;18(1):e0274081. doi: 10.1371/journal.pone.0274081. eCollection 2023. PLoS One. 2023. PMID: 36716311 Free PMC article.
Further mechanistic investigations revealed the capability of compound 16 to induce apoptosis in HCT-116 cells and arrest the growth at the S and G2/M phases. Also, compound 16 showed a significant increase in the level of BAX (2.18-fold) and a marked decrease in the level …
Further mechanistic investigations revealed the capability of compound 16 to induce apoptosis in HCT-116 cells and arrest the growth at the …
Quality and accuracy of electronic pre-anesthesia evaluation forms.
Almeshari M, Khalifa M, El-Metwally A, Househ M, Alanazi A. Almeshari M, et al. Comput Methods Programs Biomed. 2018 Jul;160:51-56. doi: 10.1016/j.cmpb.2018.03.006. Epub 2018 Mar 15. Comput Methods Programs Biomed. 2018. PMID: 29728246
Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno[2,3-d]pyrimidines targeting VEGFR-2.
El-Metwally SA, Elkady H, Hagras M, Husein DZ, Ibrahim IM, Taghour MS, El-Mahdy HA, Ismail A, Alsfouk BA, Elkaeed EB, Metwaly AM, Eissa IH. El-Metwally SA, et al. RSC Adv. 2023 Aug 4;13(33):23365-23385. doi: 10.1039/d3ra03128d. eCollection 2023 Jul 26. RSC Adv. 2023. PMID: 37545598 Free PMC article.
Further studies revealed that compound 18 induced cell cycle arrest in G2/M phase and promoted apoptosis in MCF-7 cancer cells. Apoptosis was stimulated by compound 18 by increasing BAX (3.6-fold) and decreasing Bcl-2 (3.1-fold). ...
Further studies revealed that compound 18 induced cell cycle arrest in G2/M phase and promoted apoptosis in MCF-7 cancer cells. Apopt …
Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies.
Yousef RG, Elwan A, Gobaara IMM, Mehany ABM, Eldehna WM, El-Metwally SA, A Alsfouk B, Elkaeed EB, Metwaly AM, Eissa IH. Yousef RG, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2206-2222. doi: 10.1080/14756366.2022.2110868. J Enzyme Inhib Med Chem. 2022. PMID: 35980113 Free PMC article.
Compound 10 revealed the highest anti-proliferative activities with IC(50) values of 15.4 and 9.8 M against HCT-116 and HepG2, respectively compared to sorafenib (IC(50) = 9.30 and 7.40 M). Compound 7 owned promising cytotoxic activities with IC(50) values of 15.7 a …
Compound 10 revealed the highest anti-proliferative activities with IC(50) values of 15.4 and 9.8 M against HCT-116 and HepG2, respec …
Discovery of thieno[2,3-d]pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents.
El-Metwally SA, Abou-El-Regal MM, Eissa IH, Mehany ABM, Mahdy HA, Elkady H, Elwan A, Elkaeed EB. El-Metwally SA, et al. Bioorg Chem. 2021 Jul;112:104947. doi: 10.1016/j.bioorg.2021.104947. Epub 2021 Apr 27. Bioorg Chem. 2021. PMID: 33964580
Compound 17f exhibited the highest cytotoxic activities against the examined cell lines, HCT-116 and HepG2, with IC(50) values of 2.80 0.16 and 4.10 0.45 M, respectively. Aiming at exploring the mechanism of action of these compounds, the most active cytotoxic derivatives …
Compound 17f exhibited the highest cytotoxic activities against the examined cell lines, HCT-116 and HepG2, with IC(50) values of 2.80 0.16 …
Effect of sildenafil on the isolated rat aortic rings.
Sharabi FM, Daabees TT, El-Metwally MA, Senbel AM. Sharabi FM, et al. Fundam Clin Pharmacol. 2005 Aug;19(4):449-56. doi: 10.1111/j.1472-8206.2005.00345.x. Fundam Clin Pharmacol. 2005. PMID: 16011732
Sildenafil produced significant potentiation of acetylcholine (ACh, 2 x 10(-6) m)-induced relaxation at concentration > or =1 x 10(-8) m. Addition of sildenafil (1 x 10(-7) m) to aortic rings failed to alter the effect of N(G)-nitro-L-arginine (l-NNA, 3 x …
Sildenafil produced significant potentiation of acetylcholine (ACh, 2 x 10(-6) m)-induced relaxation at concentration > or =1 x 10 …
24 results