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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1986 1
1988 1
1990 1
1991 1
1996 1
1997 2
1998 3
1999 4
2000 5
2001 5
2002 12
2003 8
2004 8
2005 5
2006 13
2007 10
2008 10
2009 9
2010 8
2011 7
2012 12
2013 6
2014 11
2015 7
2016 10
2017 4
2018 4
2019 6
2020 7
2021 12
2022 6
2023 9
2024 3

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192 results

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Page 1
The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions.
Koleske BN, Jacobs WR Jr, Bishai WR. Koleske BN, et al. J Clin Invest. 2023 Oct 2;133(19):e173156. doi: 10.1172/JCI173156. J Clin Invest. 2023. PMID: 37781921 Free PMC article. Review.
At the 25-year anniversary of this accomplishment, we describe how insights gleaned from the M. tuberculosis genome have led to vital tools for TB research, epidemiology, and clinical practice. ...
At the 25-year anniversary of this accomplishment, we describe how insights gleaned from the M. tuberculosis genome have led to vital …
Post translational modifications in tuberculosis: ubiquitination paradox.
Shariq M, Quadir N, Sheikh JA, Singh AK, Bishai WR, Ehtesham NZ, Hasnain SE. Shariq M, et al. Autophagy. 2021 Mar;17(3):814-817. doi: 10.1080/15548627.2020.1850009. Epub 2020 Nov 24. Autophagy. 2021. PMID: 33190592 Free PMC article. Review.
Innate immune signaling and xenophagy are crucial innate defense strategies exploited by the host to counteract intracellular pathogens with ubiquitination as a critical regulator of these processes. These pathogens, including Mycobacterium tuberculosis (M. tb), co-opt the …
Innate immune signaling and xenophagy are crucial innate defense strategies exploited by the host to counteract intracellular pathogens with …
Host-Directed Therapies: Modulating Inflammation to Treat Tuberculosis.
Krug S, Parveen S, Bishai WR. Krug S, et al. Front Immunol. 2021 Apr 19;12:660916. doi: 10.3389/fimmu.2021.660916. eCollection 2021. Front Immunol. 2021. PMID: 33953722 Free PMC article. Review.
The balance between the timing and expression levels of pro- and anti-inflammatory responses plays an important role in the fate of infection. Interestingly, M. tuberculosis appears to manipulate both sides of the human immune response to remodel the host environment for i …
The balance between the timing and expression levels of pro- and anti-inflammatory responses plays an important role in the fate of infectio …
MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival.
Bullen CK, Singh AK, Krug S, Lun S, Thakur P, Srikrishna G, Bishai WR. Bullen CK, et al. JCI Insight. 2023 Oct 23;8(20):e166242. doi: 10.1172/jci.insight.166242. JCI Insight. 2023. PMID: 37725440 Free PMC article.
To further define the role of MDA5 in M. tuberculosis pathogenesis, we evaluated M. tuberculosis intracellular growth and innate immune responses in WT and Mda5-/- macrophages. ...In the mouse TB model, loss of MDA5 conferred host survival benefits with a concomitan …
To further define the role of MDA5 in M. tuberculosis pathogenesis, we evaluated M. tuberculosis intracellular growth and inna …
Genetic and hormonal mechanisms underlying sex-specific immune responses in tuberculosis.
Gupta M, Srikrishna G, Klein SL, Bishai WR. Gupta M, et al. Trends Immunol. 2022 Aug;43(8):640-656. doi: 10.1016/j.it.2022.06.004. Epub 2022 Jul 13. Trends Immunol. 2022. PMID: 35842266 Free PMC article. Review.
Tuberculosis (TB), the world's deadliest bacterial infection, afflicts more human males than females, with a male/female (M/F) ratio of 1.7. Sex disparities in TB prevalence, pathophysiology, and clinical manifestations are widely reported, but the underlying biological me …
Tuberculosis (TB), the world's deadliest bacterial infection, afflicts more human males than females, with a male/female (M/F) ratio …
Fluoroquinolones, tuberculosis, and resistance.
Ginsburg AS, Grosset JH, Bishai WR. Ginsburg AS, et al. Lancet Infect Dis. 2003 Jul;3(7):432-42. doi: 10.1016/s1473-3099(03)00671-6. Lancet Infect Dis. 2003. PMID: 12837348 Review.
With increasing numbers of fluoroquinolone prescriptions and the expanded use of these broad-spectrum agents for many infections, the selective pressure of fluoroquinolone use results in the ready emergence of fluoroquinolone resistance in a diversity of organisms, including M …
With increasing numbers of fluoroquinolone prescriptions and the expanded use of these broad-spectrum agents for many infections, the select …
192 results