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Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.
Horwitz S, O'Connor OA, Pro B, Illidge T, Fanale M, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Lennard A, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Iyer S, Zinzani PL, Hua Z, Little M, Rao S, Woolery J, Manley T, Trümper L; ECHELON-2 Study Group. Horwitz S, et al. Lancet. 2019 Jan 19;393(10168):229-240. doi: 10.1016/S0140-6736(18)32984-2. Epub 2018 Dec 4. Lancet. 2019. PMID: 30522922 Free PMC article. Clinical Trial.
Randomisation was stratified by histological subtype according to local pathology assessment and by international prognostic index score. All patients received cyclophosphamide 750 mg/m(2) and doxorubicin 50 mg/m(2) on day 1 of each cycle intravenously and prednison …
Randomisation was stratified by histological subtype according to local pathology assessment and by international prognostic index score. Al …
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.
Baloni P, Arnold M, Buitrago L, Nho K, Moreno H, Huynh K, Brauner B, Louie G, Kueider-Paisley A, Suhre K, Saykin AJ, Ekroos K, Meikle PJ, Hood L, Price ND; Alzheimer’s Disease Metabolomics Consortium; Doraiswamy PM, Funk CC, Hernández AI, Kastenmüller G, Baillie R, Han X, Kaddurah-Daouk R. Baloni P, et al. Commun Biol. 2022 Oct 8;5(1):1074. doi: 10.1038/s42003-022-04011-6. Commun Biol. 2022. PMID: 36209301 Free PMC article.
Robust SARS-CoV-2 T cell responses with common TCRalphabeta motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells.
Nguyen THO, Rowntree LC, Allen LF, Chua BY, Kedzierski L, Lim C, Lasica M, Tennakoon GS, Saunders NR, Crane M, Chee L, Seymour JF, Anderson MA, Whitechurch A, Clemens EB, Zhang W, Chang SY, Habel JR, Jia X, McQuilten HA, Minervina AA, Pogorelyy MV, Chaurasia P, Petersen J, Menon T, Hensen L, Neil JA, Mordant FL, Tan HX, Cabug AF, Wheatley AK, Kent SJ, Subbarao K, Karapanagiotidis T, Huang H, Vo LK, Cain NL, Nicholson S, Krammer F, Gibney G, James F, Trevillyan JM, Trubiano JA, Mitchell J, Christensen B, Bond KA, Williamson DA, Rossjohn J, Crawford JC, Thomas PG, Thursky KA, Slavin MA, Tam CS, Teh BW, Kedzierska K. Nguyen THO, et al. Cell Rep Med. 2023 Apr 18;4(4):101017. doi: 10.1016/j.xcrm.2023.101017. Epub 2023 Mar 27. Cell Rep Med. 2023. PMID: 37030296 Free PMC article.
Importantly, vaccine-induced expansions of spike-specific and peptide-HLA tetramer-specific CD4(+)/CD8(+) T cells, together with their T cell receptor (TCR) repertoires, were robust in hematology patients, irrespective of B cell numbers, and comparable to healthy pa …
Importantly, vaccine-induced expansions of spike-specific and peptide-HLA tetramer-specific CD4(+)/CD8(+) T cells, together with thei …
Comparison of Prehospital Assessment by Paramedics and In-Hospital Assessment by Physicians in Suspected Stroke Patients: Results From 2 Prospective Cohort Studies.
Dekker L, Daems JD, Duvekot MHC, Nguyen TTM, Venema E, van Es ACGM, Rozeman AD, Moudrous W, Dorresteijn KRIS, Hensen JJ, Bosch J, van Zwet EW, de Schryver ELLM, Kloos LMH, de Laat KF, Aerden LAM, van den Wijngaard IR, Dippel DWJ, Kerkhoff H, Wermer MJH, Roozenbeek B, Kruyt ND; LPSS and PRESTO Investigators. Dekker L, et al. Stroke. 2023 Sep;54(9):2279-2285. doi: 10.1161/STROKEAHA.123.042644. Epub 2023 Jul 19. Stroke. 2023. PMID: 37465998
CD8(+) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph.
Hensen L, Illing PT, Bridie Clemens E, Nguyen THO, Koutsakos M, van de Sandt CE, Mifsud NA, Nguyen AT, Szeto C, Chua BY, Halim H, Rizzetto S, Luciani F, Loh L, Grant EJ, Saunders PM, Brooks AG, Rockman S, Kotsimbos TC, Cheng AC, Richards M, Westall GP, Wakim LM, Loudovaris T, Mannering SI, Elliott M, Tangye SG, Jackson DC, Flanagan KL, Rossjohn J, Gras S, Davies J, Miller A, Tong SYC, Purcell AW, Kedzierska K. Hensen L, et al. Nat Commun. 2021 May 18;12(1):2931. doi: 10.1038/s41467-021-23212-x. Nat Commun. 2021. PMID: 34006841 Free PMC article.
We identify immunodominant protective CD8(+) T-cell epitopes, one towards IAV and six towards IBV, with A24/PB2(550-558)-specific CD8(+) T cells being cross-reactive between IAV and IBV. ...Our data show influenza-specific CD8(+) T-cell responses in Indigenou …
We identify immunodominant protective CD8(+) T-cell epitopes, one towards IAV and six towards IBV, with A24/PB2(550-558)-specific CD8 …
Mechanoenzymatics of titin kinase.
Puchner EM, Alexandrovich A, Kho AL, Hensen U, Schäfer LV, Brandmeier B, Gräter F, Grubmüller H, Gaub HE, Gautel M. Puchner EM, et al. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13385-90. doi: 10.1073/pnas.0805034105. Epub 2008 Sep 2. Proc Natl Acad Sci U S A. 2008. PMID: 18765796 Free PMC article.
In vertebrate muscle, the giant elastic protein titin is involved in strain sensing via its C-terminal kinase domain (TK) at the sarcomeric M-band and contributes to the adaptation of muscle in response to changes in mechanical strain. ...
In vertebrate muscle, the giant elastic protein titin is involved in strain sensing via its C-terminal kinase domain (TK) at the sarcomeric …
Eight-coordinate fluoride in a silicate double-four-ring.
Goesten MG, Hoffmann R, Bickelhaupt FM, Hensen EJ. Goesten MG, et al. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):828-833. doi: 10.1073/pnas.1615742114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096342 Free PMC article.
The embryonic node behaves as an instructive stem cell niche for axial elongation.
Solovieva T, Lu HC, Moverley A, Plachta N, Stern CD. Solovieva T, et al. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2108935119. doi: 10.1073/pnas.2108935119. Proc Natl Acad Sci U S A. 2022. PMID: 35101917 Free PMC article.
In warm-blooded vertebrate embryos (mammals and birds), the axial tissues of the body form from a growth zone at the tail end, Hensen's node, which generates neural, mesodermal, and endodermal structures along the midline. ...Long-term resident cells are restricted to the …
In warm-blooded vertebrate embryos (mammals and birds), the axial tissues of the body form from a growth zone at the tail end, Hensen …
62 results