p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin.
Loonat AA, Martin ED, Sarafraz-Shekary N, Tilgner K, Hertz NT, Levin R, Shokat KM, Burlingame AL, Arabacilar P, Uddin S, Thomas M, Marber MS, Clark JE.
Loonat AA, et al.
FASEB J. 2019 Dec;33(12):13131-13144. doi: 10.1096/fj.201701545R. Epub 2019 Oct 22.
FASEB J. 2019.
PMID: 31638431
Free PMC article.
In addition, we have identified calpastatin, among other substrates, as a novel direct target of p38gamma that may contribute to the protection observed in p38gammaKO mice.-Loonat, A. A., Martin, E. D., Sarafraz-Shekary, N., Tilgner, K., Hertz, N. T., Levin, R., Shokat, K. …
In addition, we have identified calpastatin, among other substrates, as a novel direct target of p38gamma that may contribute to the protect …