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2019 2
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Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases.
Homilius M, Zhu W, Eddy SS, Thompson PC, Zheng H, Warren CN, Evans CG, Kim DD, Xuan LL, Nsubuga C, Strecker Z, Pettit CJ, Cho J, Howie MN, Thaler AS, Wilson E, Wollison B, Smith C, Nascimben JB, Nascimben DN, Lunati GM, Folks HC, Cupelo M, Sridaran S, Rheinstein C, McClennen T, Goto S, Truslow JG, Vandenwijngaert S, MacRae CA, Deo RC. Homilius M, et al. Among authors: xuan ll. Nat Genet. 2024 Jan;56(1):37-50. doi: 10.1038/s41588-023-01600-x. Epub 2023 Dec 4. Nat Genet. 2024. PMID: 38049662 Free PMC article.
Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration.
Sánchez-Rivera FJ, Ryan J, Soto-Feliciano YM, Clare Beytagh M, Xuan L, Feldser DM, Hemann MT, Zamudio J, Dimitrova N, Letai A, Jacks T. Sánchez-Rivera FJ, et al. Among authors: xuan l. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2019740118. doi: 10.1073/pnas.2019740118. Proc Natl Acad Sci U S A. 2021. PMID: 34074758 Free PMC article.
Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion.
Zhao WN, Tobe BTD, Udeshi ND, Xuan LL, Pernia CD, Zolg DP, Roberts AJ, Mani D, Blumenthal SR, Kurtser I, Patnaik D, Gaisina I, Bishop J, Sheridan SD, Lalonde J, Carr SA, Snyder EY, Haggarty SJ. Zhao WN, et al. Among authors: xuan ll. Transl Psychiatry. 2020 Feb 24;10(1):76. doi: 10.1038/s41398-020-0753-6. Transl Psychiatry. 2020. PMID: 32094324 Free PMC article.
Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.
Bernard-Gauthier V, Mossine AV, Knight A, Patnaik D, Zhao WN, Cheng C, Krishnan HS, Xuan LL, Chindavong PS, Reis SA, Chen JM, Shao X, Stauff J, Arteaga J, Sherman P, Salem N, Bonsall D, Amaral B, Varlow C, Wells L, Martarello L, Patel S, Liang SH, Kurumbail RG, Haggarty SJ, Scott PJH, Vasdev N. Bernard-Gauthier V, et al. Among authors: xuan ll. J Med Chem. 2019 Nov 14;62(21):9600-9617. doi: 10.1021/acs.jmedchem.9b01030. Epub 2019 Oct 21. J Med Chem. 2019. PMID: 31535859 Free PMC article.