Oral delivery of camptothecin-loaded multifunctional chitosan-based micelles is effective in reduce colorectal cancer.
Almeida A, Castro F, Resende C, Lúcio M, Schwartz S Jr, Sarmento B.
Almeida A, et al.
J Control Release. 2022 Sep;349:731-743. doi: 10.1016/j.jconrel.2022.07.029. Epub 2022 Jul 30.
J Control Release. 2022.
PMID: 35905784
Free article.
In a more complex 3D CRC multicellular spheroid model, CPT-loaded micelles also exhibited a significant effect on the spheroid's metabolic activity and size reduction. Remarkably, in vivo studies performed in a HCT116 xenograft model, showed a significant reduction on the …
In a more complex 3D CRC multicellular spheroid model, CPT-loaded micelles also exhibited a significant effect on the spheroid's meta …