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The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone.
Oliveira VDS, Silva CC, de Freitas Oliveira JW, da Silva MS, Ferreira PG, da Siva FC, Ferreira VF, Barbosa EG, Barbosa CG, Moraes CB, Freitas-Junior LHG, Converti A, Lima ÁAN. Oliveira VDS, et al. J Drug Deliv Sci Technol. 2023 Mar;81:104229. doi: 10.1016/j.jddst.2023.104229. Epub 2023 Feb 8. J Drug Deliv Sci Technol. 2023. PMID: 36776572 Free PMC article.
SARS-CoV-2 Spike protein peptides displayed in the Pyrococcus furiosus RAD system preserve epitopes antigenicity, immunogenicity, and virus-neutralizing activity of antibodies.
Cioffi VB, de Castro-Amarante MF, Lulla A, Andreata-Santos R, Cruz MC, Moreno ACR, de Oliveira Silva M, de Miranda Peres B, de Freitas Junior LHG, Moraes CB, Durigon EL, Gordon NC, Hyvönen M, de Souza Ferreira LC, Balan A. Cioffi VB, et al. Sci Rep. 2023 Oct 5;13(1):16821. doi: 10.1038/s41598-023-43720-8. Sci Rep. 2023. PMID: 37798298 Free PMC article.
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement.
Gomes JC, Cianni L, Ribeiro J, Dos Reis Rocho F, da Costa Martins Silva S, Batista PHJ, Moraes CB, Franco CH, Freitas-Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, de Vita D, Montanari CA. Gomes JC, et al. Among authors: freitas junior lhg. Bioorg Med Chem. 2019 Nov 15;27(22):115083. doi: 10.1016/j.bmc.2019.115083. Epub 2019 Aug 28. Bioorg Med Chem. 2019. PMID: 31561938
Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors.
Freire MCLC, Noske GD, Bitencourt NV, Sanches PRS, Santos-Filho NA, Gawriljuk VO, de Souza EP, Nogueira VHR, de Godoy MO, Nakamura AM, Fernandes RS, Godoy AS, Juliano MA, Peres BM, Barbosa CG, Moraes CB, Freitas-Junior LHG, Cilli EM, Guido RVC, Oliva G. Freire MCLC, et al. Among authors: freitas junior lhg. Molecules. 2021 Aug 12;26(16):4896. doi: 10.3390/molecules26164896. Molecules. 2021. PMID: 34443484 Free PMC article.
Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander (Salamandra salamandra).
Barros ALAN, Silva VC, Ribeiro-Junior AF, Cardoso MG, Costa SR, Moraes CB, Barbosa CG, Coleone AP, Simões RP, Cabral WF, Falcão RM, Vasconcelos AG, Rocha JA, Arcanjo DDR, Batagin-Neto A, Borges TKS, Gonçalves J, Brand GD, Freitas-Junior LHG, Eaton P, Marani M, Kato MJ, Plácido A, Leite JRSA. Barros ALAN, et al. Among authors: freitas junior lhg. Pharmaceutics. 2024 Jan 29;16(2):190. doi: 10.3390/pharmaceutics16020190. Pharmaceutics. 2024. PMID: 38399250 Free PMC article.