Novel BCL2 mutations in venetoclax-resistant, ibrutinib-resistant CLL patients with BTK/PLCG2 mutations

Blood. 2020 Jun 11;135(24):2192-2195. doi: 10.1182/blood.2019003722.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives
  • Adenine / therapeutic use
  • Agammaglobulinaemia Tyrosine Kinase / genetics*
  • Aged
  • Antineoplastic Agents / therapeutic use
  • Bridged Bicyclo Compounds, Heterocyclic / therapeutic use
  • Drug Resistance, Neoplasm / genetics*
  • Female
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Male
  • Middle Aged
  • Molecular Targeted Therapy
  • Mutation*
  • Phospholipase C gamma / genetics*
  • Piperidines / therapeutic use
  • Proto-Oncogene Proteins c-bcl-2 / genetics*
  • Sulfonamides / therapeutic use

Substances

  • Antineoplastic Agents
  • BCL2 protein, human
  • Bridged Bicyclo Compounds, Heterocyclic
  • Piperidines
  • Proto-Oncogene Proteins c-bcl-2
  • Sulfonamides
  • ibrutinib
  • Agammaglobulinaemia Tyrosine Kinase
  • BTK protein, human
  • PLCG2 protein, human
  • Phospholipase C gamma
  • Adenine
  • venetoclax