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Showing results for labor fiser a
Your search for Lubor Fisera retrieved no results
Chi3l1 Is a Modulator of Glioma Stem Cell States and a Therapeutic Target in Glioblastoma.
Guetta-Terrier C, Karambizi D, Akosman B, Zepecki JP, Chen JS, Kamle S, Fajardo JE, Fiser A, Singh R, Toms SA, Lee CG, Elias JA, Tapinos N. Guetta-Terrier C, et al. Among authors: fiser a. Cancer Res. 2023 Jun 15;83(12):1984-1999. doi: 10.1158/0008-5472.CAN-21-3629. Cancer Res. 2023. PMID: 37101376 Free PMC article.
Finally, targeting Chi3l1 in vivo with a blocking antibody inhibited tumor growth and increased the probability of survival. Overall, this work suggests that Chi3l1 interacts with CD44 on the surface of GSCs to induce Akt/beta-catenin signaling and MAZ transcriptional acti …
Finally, targeting Chi3l1 in vivo with a blocking antibody inhibited tumor growth and increased the probability of survival. Overall, this …
Integrated structure-based protein interface prediction.
Walder M, Edelstein E, Carroll M, Lazarev S, Fajardo JE, Fiser A, Viswanathan R. Walder M, et al. Among authors: fiser a. BMC Bioinformatics. 2022 Jul 25;23(1):301. doi: 10.1186/s12859-022-04852-2. BMC Bioinformatics. 2022. PMID: 35879651 Free PMC article.
The method is robust and performs well even when one of the individual classifiers performs poorly on a particular query protein. This work demonstrates that integrating orthogonal methods that depend on different structural properties of proteins performs better at interf …
The method is robust and performs well even when one of the individual classifiers performs poorly on a particular query protein. This wo …
Development of a motif-based topology-independent structure comparison method to identify evolutionarily related folds.
Dybas JM, Fiser A. Dybas JM, et al. Among authors: fiser a. Proteins. 2016 Dec;84(12):1859-1874. doi: 10.1002/prot.25169. Epub 2016 Oct 11. Proteins. 2016. PMID: 27671894 Free PMC article.
SmotifCOMP is used to perform an exhaustive comparison of the known folds and the identified relationships are used to produce a nonhierarchical representation of the fold space that reflects the notion of a continuous and connected fold universe. The current work offers i …
SmotifCOMP is used to perform an exhaustive comparison of the known folds and the identified relationships are used to produce a nonhierarch …
A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation.
Zhan HQ, Najmi M, Lin K, Aluri S, Fiser A, Goldman ID, Zhao R. Zhan HQ, et al. Among authors: fiser a. J Biol Chem. 2020 Nov 13;295(46):15650-15661. doi: 10.1074/jbc.RA120.014757. Epub 2020 Sep 6. J Biol Chem. 2020. PMID: 32893190 Free PMC article.
The proton-coupled folate transporter (PCFT, SLC46A1) is required for folate intestinal absorption and transport across the choroid plexus. Recent work has identified a F392V mutation causing hereditary folate malabsorption. ...
The proton-coupled folate transporter (PCFT, SLC46A1) is required for folate intestinal absorption and transport across the choroid plexus. …
The choice of sequence homologs included in multiple sequence alignments has a dramatic impact on evolutionary conservation analysis.
Gil N, Fiser A. Gil N, et al. Among authors: fiser a. Bioinformatics. 2019 Jan 1;35(1):12-19. doi: 10.1093/bioinformatics/bty523. Bioinformatics. 2019. PMID: 29947739 Free PMC article.
Additionally, we showcase the progress in this direction made by Selection of Alignment by Maximal Mutual Information (SAMMI), an information-theory-based approach to identifying biologically informative MSAs. This work highlights the importance and the unused potential of …
Additionally, we showcase the progress in this direction made by Selection of Alignment by Maximal Mutual Information (SAMMI), an informatio …
New statistical potential for quality assessment of protein models and a survey of energy functions.
Rykunov D, Fiser A. Rykunov D, et al. Among authors: fiser a. BMC Bioinformatics. 2010 Mar 12;11:128. doi: 10.1186/1471-2105-11-128. BMC Bioinformatics. 2010. PMID: 20226048 Free PMC article.
Atom- and residue-level statistical potentials and Linux executables to calculate the energy of a given protein proposed in this work can be downloaded from http://www.fiserlab.org/potentials. CONCLUSIONS: Among the most influential terms we observed a critical role of a p …
Atom- and residue-level statistical potentials and Linux executables to calculate the energy of a given protein proposed in this work …
Functional clustering of immunoglobulin superfamily proteins with protein-protein interaction information calibrated hidden Markov model sequence profiles.
Yap EH, Rosche T, Almo S, Fiser A. Yap EH, et al. Among authors: fiser a. J Mol Biol. 2014 Feb 20;426(4):945-61. doi: 10.1016/j.jmb.2013.11.009. Epub 2013 Nov 16. J Mol Biol. 2014. PMID: 24246499 Free PMC article.
An essential activity of the ectodomains of these proteins is the specific recognition of cognate ligands, which are often other members of the IgSF. In this work, we provide functional insight for this important class of proteins through the development of a clustering al …
An essential activity of the ectodomains of these proteins is the specific recognition of cognate ligands, which are often other members of …