Bioactive ZnO Coatings Deposited by MAPLE-An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces

Molecules. 2016 Feb 16;21(2):220. doi: 10.3390/molecules21020220.

Abstract

Deposition of bioactive coatings composed of zinc oxide, cyclodextrin and cefepime (ZnO/CD/Cfp) was performed by the Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The obtained nanostructures were characterized by X-ray diffraction, IR microscopy and scanning electron microscopy. The efficient release of cefepime was correlated with an increased anti-biofilm activity of ZnO/CD/Cfp composites. In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications. The release of the fourth generation cephalosporin Cfp in a biologically active form from the ZnO matrix could help preventing the bacterial adhesion and the subsequent colonization and biofilm development on various surfaces, and thus decreasing the risk of biofilm-related infections.

Keywords: MAPLE; biofilm inhibition; cyclodextrins; drug delivery; modified surface; zinc oxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / chemistry*
  • Biofilms / drug effects
  • Cefepime
  • Cephalosporins / chemistry
  • Cephalosporins / pharmacology
  • Coated Materials, Biocompatible / administration & dosage
  • Coated Materials, Biocompatible / chemistry*
  • Cyclodextrins / chemistry
  • Cyclodextrins / pharmacology
  • Mice
  • Nanostructures / chemistry*
  • X-Ray Diffraction
  • Zinc Oxide / chemistry*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Coated Materials, Biocompatible
  • Cyclodextrins
  • Cefepime
  • Zinc Oxide