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Showing results for linking lyu
Search for Linjing Lyu instead (3 results)
Sensory circuitry controls cytosolic calcium-mediated phytochrome B phototransduction.
Zhao Y, Shi H, Pan Y, Lyu M, Yang Z, Kou X, Deng XW, Zhong S. Zhao Y, et al. Cell. 2023 Mar 16;186(6):1230-1243.e14. doi: 10.1016/j.cell.2023.02.011. Cell. 2023. PMID: 36931246
Our results uncover a biochemical regulatory loop centered in phyB phototransduction and provide a paradigm for linking ubiquitous Ca(2+) increases to specific responses in sensory stimulus processing....
Our results uncover a biochemical regulatory loop centered in phyB phototransduction and provide a paradigm for linking ubiquitous Ca …
Organoid technology and applications in cancer research.
Xu H, Lyu X, Yi M, Zhao W, Song Y, Wu K. Xu H, et al. J Hematol Oncol. 2018 Sep 15;11(1):116. doi: 10.1186/s13045-018-0662-9. J Hematol Oncol. 2018. PMID: 30219074 Free PMC article. Review.
Up to now, highly efficient establishment of organoids can be achieved from both normal and malignant tissues of patients. Using this bioengineered platform, the links of infection-cancer progression and mutation-carcinogenesis are feasible to be modeled. ...
Up to now, highly efficient establishment of organoids can be achieved from both normal and malignant tissues of patients. Using this bioeng …
5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs.
Chen X, Li A, Sun BF, Yang Y, Han YN, Yuan X, Chen RX, Wei WS, Liu Y, Gao CC, Chen YS, Zhang M, Ma XD, Liu ZW, Luo JH, Lyu C, Wang HL, Ma J, Zhao YL, Zhou FJ, Huang Y, Xie D, Yang YG. Chen X, et al. Nat Cell Biol. 2019 Aug;21(8):978-990. doi: 10.1038/s41556-019-0361-y. Epub 2019 Jul 29. Nat Cell Biol. 2019. PMID: 31358969
We identify numerous oncogene RNAs with hypermethylated m(5)C sites causally linked to their upregulation in UCBs and further demonstrate YBX1 as an m(5)C 'reader' recognizing m(5)C-modified mRNAs through the indole ring of W65 in its cold-shock domain. ...
We identify numerous oncogene RNAs with hypermethylated m(5)C sites causally linked to their upregulation in UCBs and further demonst …
Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration.
Tang Q, Lu B, He J, Chen X, Fu Q, Han H, Luo C, Yin H, Qin Z, Lyu D, Zhang L, Zhou M, Yao K. Tang Q, et al. Biomaterials. 2022 Jan;280:121320. doi: 10.1016/j.biomaterials.2021.121320. Epub 2021 Dec 11. Biomaterials. 2022. PMID: 34923312
Our findings indicate that iPSC-MSCs secrete miRNA-containing exosomes to promote corneal epithelium and stroma regeneration, and that miR-432-5p can prevent ECM deposition via a mechanism most probably linked to direct repression of its target gene TRAM2. Overall, our exo …
Our findings indicate that iPSC-MSCs secrete miRNA-containing exosomes to promote corneal epithelium and stroma regeneration, and that miR-4 …
Replication timing maintains the global epigenetic state in human cells.
Klein KN, Zhao PA, Lyu X, Sasaki T, Bartlett DA, Singh AM, Tasan I, Zhang M, Watts LP, Hiraga SI, Natsume T, Zhou X, Baslan T, Leung D, Kanemaki MT, Donaldson AD, Zhao H, Dalton S, Corces VG, Gilbert DM. Klein KN, et al. Science. 2021 Apr 23;372(6540):371-378. doi: 10.1126/science.aba5545. Epub 2021 Apr 22. Science. 2021. PMID: 33888635 Free PMC article.
The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin modifications and three-dimensional genome architecture; however, causal links have not been established, largely because of an inability to manipulate the global RT program. ...
The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin modifications and three-dimensional genome arch …
FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma.
Wang Y, Lyu Z, Qin Y, Wang X, Sun L, Zhang Y, Gong L, Wu S, Han S, Tang Y, Jia Y, Kwong DL, Kam N, Guan XY. Wang Y, et al. Theranostics. 2020 Sep 16;10(25):11535-11548. doi: 10.7150/thno.45261. eCollection 2020. Theranostics. 2020. PMID: 33052231 Free PMC article.
Methods: FOXO1 expression and macrophage infiltration in clinical samples and mouse models were quantified using quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry staining. Western blotting, qRT-PCR, and enzyme-linked immunosorbent assay w …
Methods: FOXO1 expression and macrophage infiltration in clinical samples and mouse models were quantified using quantitative real-time poly …
Altered faecal microbiome and metabolome in IgG4-related sclerosing cholangitis and primary sclerosing cholangitis.
Liu Q, Li B, Li Y, Wei Y, Huang B, Liang J, You Z, Li Y, Qian Q, Wang R, Zhang J, Chen R, Lyu Z, Chen Y, Shi M, Xiao X, Wang Q, Miao Q, Fang JY, Gershwin ME, Lian M, Ma X, Tang R. Liu Q, et al. Gut. 2022 May;71(5):899-909. doi: 10.1136/gutjnl-2020-323565. Epub 2021 May 25. Gut. 2022. PMID: 34035120
Notable depletion of Blautia and elevated succinic acid may underlie hepatic inflammation in IgG4-SC. In comparison, potential links between the microbial or metabolic signatures and cholestatic parameters were detected in PSC. ...
Notable depletion of Blautia and elevated succinic acid may underlie hepatic inflammation in IgG4-SC. In comparison, potential links …
Chronic social isolation signals starvation and reduces sleep in Drosophila.
Li W, Wang Z, Syed S, Lyu C, Lincoln S, O'Neil J, Nguyen AD, Feng I, Young MW. Li W, et al. Nature. 2021 Sep;597(7875):239-244. doi: 10.1038/s41586-021-03837-0. Epub 2021 Aug 18. Nature. 2021. PMID: 34408325 Free PMC article.
Research in social psychology suggests that compromised sleep quality is a key factor that links persistent loneliness to adverse health conditions(5,6). Although experimental manipulations have been widely applied to studying the control of sleep and wakefulness in animal …
Research in social psychology suggests that compromised sleep quality is a key factor that links persistent loneliness to adverse hea …
TLR4 aggravates microglial pyroptosis by promoting DDX3X-mediated NLRP3 inflammasome activation via JAK2/STAT1 pathway after spinal cord injury.
Wang J, Zhang F, Xu H, Yang H, Shao M, Xu S, Lyu F. Wang J, et al. Clin Transl Med. 2022 Jun;12(6):e894. doi: 10.1002/ctm2.894. Clin Transl Med. 2022. PMID: 35692100 Free PMC article.
A series of molecular biological experiments, including Western blot (WB), real-time quantitative polymerase chain reaction (RT-qPCR), enzyme-linked immunosorbent assay (ELISA), immunofluorescence (IF), immunohistochemical (IHC), chromatin immunoprecipitation (ChIP), Dual- …
A series of molecular biological experiments, including Western blot (WB), real-time quantitative polymerase chain reaction (RT-qPCR), enzym …
510 results