Deuterium-Depleted Water Influence on the Isotope ²H/¹H Regulation in Body and Individual Adaptation

This review article presents data about the influence of deuterium-depleted water (DDW) on biological systems. It is known that the isotope abundances of natural and bottled waters are variable worldwide. That is why different drinking rations lead to changes of stable isotopes content in body water fluxes in human and animal organisms. Also, intracellular water isotope ratios in living systems depends on metabolic activity and food consumption. We found the ²H/¹H gradient in human fluids (δ²H _saliva >> δ²H _{blood plasma} > δ²H_{breast milk}), which decreases significantly during DDW intake. Moreover, DDW induces several important biological effects in organism (antioxidant, metabolic detoxification, anticancer, rejuvenation, behavior, etc.). Changing the isotope ²H/¹H gradient from "²H _{blood plasma} > δ²H _{visceral organs}" to "δ²H _{blood plasma} << δ²H _{visceral organs}" via DDW drinking increases individual adaptation by isotopic shock. The other possible mechanisms of long-term adaptation is DDW influence on the growth rate of cells, enzyme activity and cellular energetics (e.g., stimulation of the mitochondrion activity). In addition, DDW reduces the number of single-stranded DNA breaks and modifies the miRNA profile.