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The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling.
Sałaciak K, Głuch-Lutwin M, Siwek A, Szafarz M, Kazek G, Bednarski M, Nowiński L, Mitchell E, Jastrzębska-Więsek M, Partyka A, Wesołowska A, Kołaczkowski M, Szkaradek N, Marona H, Sapa J, Pytka K. Sałaciak K, et al. Among authors: nowinski l. J Psychopharmacol. 2020 Dec;34(12):1431-1442. doi: 10.1177/0269881120959605. Epub 2020 Oct 24. J Psychopharmacol. 2020. PMID: 33103555
Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
Zajdel P, Kos T, Marciniec K, Satała G, Canale V, Kamiński K, Hołuj M, Lenda T, Koralewski R, Bednarski M, Nowiński L, Wójcikowski J, Daniel WA, Nikiforuk A, Nalepa I, Chmielarz P, Kuśmierczyk J, Bojarski AJ, Popik P. Zajdel P, et al. Among authors: nowinski l. Eur J Med Chem. 2018 Feb 10;145:790-804. doi: 10.1016/j.ejmech.2018.01.002. Epub 2018 Jan 3. Eur J Med Chem. 2018. PMID: 29407591
Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α1A/α1D-Adrenergic Receptor Antagonist with Potential Uroselective Profile.
Canale V, Rak A, Kotańska M, Knutelska J, Siwek A, Bednarski M, Nowiński L, Zygmunt M, Koczurkiewicz P, Pękala E, Sapa J, Zajdel P. Canale V, et al. Among authors: nowinski l. Molecules. 2018 Aug 29;23(9):2175. doi: 10.3390/molecules23092175. Molecules. 2018. PMID: 30158432 Free PMC article.
Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action.
Kubacka M, Mogilski S, Bednarski M, Nowiński L, Dudek M, Żmudzka E, Siwek A, Waszkielewicz AM, Marona H, Satała G, Bojarski A, Filipek B, Pytka K. Kubacka M, et al. Among authors: nowinski l. Pharmacol Biochem Behav. 2016 Feb;141:28-41. doi: 10.1016/j.pbb.2015.11.013. Epub 2015 Dec 2. Pharmacol Biochem Behav. 2016. PMID: 26647362
Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity.
Rak A, Canale V, Marciniec K, Żmudzki P, Kotańska M, Knutelska J, Siwek A, Stachowicz G, Bednarski M, Nowiński L, Zygmunt M, Zajdel P, Sapa J. Rak A, et al. Among authors: nowinski l. Bioorg Med Chem. 2016 Nov 1;24(21):5582-5591. doi: 10.1016/j.bmc.2016.09.017. Epub 2016 Sep 10. Bioorg Med Chem. 2016. PMID: 27658792
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