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Showing results for lamin xiao
Search for Lemin Xiao instead (1 results)
Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases.
Peng Y, Tang Q, Xiao F, Fu N. Peng Y, et al. Front Pharmacol. 2022 Feb 25;13:820857. doi: 10.3389/fphar.2022.820857. eCollection 2022. Front Pharmacol. 2022. PMID: 35281936 Free PMC article. Review.
Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively. ...Among those diseases, the mechanism of lamin has been widely discuss …
Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin …
A Lamin Family-Based Signature Predicts Prognosis and Immunotherapy Response in Hepatocellular Carcinoma.
Yang Y, Xiao W, Liu R, Gao L, Chen J, Kan H. Yang Y, et al. J Immunol Res. 2022 Nov 10;2022:4983532. doi: 10.1155/2022/4983532. eCollection 2022. J Immunol Res. 2022. PMID: 36405011 Free PMC article.
BACKGROUND: Lamin family members play crucial roles in promoting oncogenesis and cancer development. ...Our research is aimed at comprehensively estimating the clinical significance of lamin family in hepatocellular carcinoma and constructing a novel lamin fa …
BACKGROUND: Lamin family members play crucial roles in promoting oncogenesis and cancer development. ...Our research is aimed at comp …
Phosphorylation of Lamin A/C at serine 22 modulates Na(v) 1.5 function.
Olaopa MA, Ai T, Chao B, Xiao X, Vatta M, Habecker BA. Olaopa MA, et al. Physiol Rep. 2021 Nov;9(22):e15121. doi: 10.14814/phy2.15121. Physiol Rep. 2021. PMID: 34806324 Free PMC article.
Variants in the LMNA gene, which encodes for Lamin A/C, are associated with cardiac conduction disease (CCD). ...Decreased peak I(Na) in the cardiac conduction system could account for patients' atrioventricular block. We found that serine 22 (Ser 22) phosphorylation of …
Variants in the LMNA gene, which encodes for Lamin A/C, are associated with cardiac conduction disease (CCD). ...Decreased peak I(Na) …
Lamin B1 is a potential therapeutic target and prognostic biomarker for hepatocellular carcinoma.
Yang Y, Gao L, Chen J, Xiao W, Liu R, Kan H. Yang Y, et al. Bioengineered. 2022 Apr;13(4):9211-9231. doi: 10.1080/21655979.2022.2057896. Bioengineered. 2022. PMID: 35436411 Free PMC article.
Hepatocellular carcinoma (HCC) is an aggressive malignancy. Previous studies have found that lamin B1 (LMNB1) contributes to the development of human cancers. ...
Hepatocellular carcinoma (HCC) is an aggressive malignancy. Previous studies have found that lamin B1 (LMNB1) contributes to the deve …
Lamin A/C negatively regulated by miR-124-3p modulates apoptosis of vascular smooth muscle cells during cyclic stretch application in rats.
Bao H, Li HP, Shi Q, Huang K, Chen XH, Chen YX, Han Y, Xiao Q, Yao QP, Qi YX. Bao H, et al. Acta Physiol (Oxf). 2020 Mar;228(3):e13374. doi: 10.1111/apha.13374. Epub 2019 Sep 27. Acta Physiol (Oxf). 2020. PMID: 31495066
AIM: Apoptosis of vascular smooth muscle cells (VSMCs) influenced by abnormal cyclic stretch is crucial for vascular remodelling during hypertension. Lamin A/C, a nuclear envelope protein, is mechano-responsive, but the role of lamin A/C in VSMC apoptosis is still u …
AIM: Apoptosis of vascular smooth muscle cells (VSMCs) influenced by abnormal cyclic stretch is crucial for vascular remodelling during hype …
A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks.
Li BX, Chen J, Chao B, Zheng Y, Xiao X. Li BX, et al. ACS Cent Sci. 2018 Sep 26;4(9):1201-1210. doi: 10.1021/acscentsci.8b00379. Epub 2018 Sep 17. ACS Cent Sci. 2018. PMID: 30276254 Free PMC article.
Nuclear lamins are type V intermediate filament proteins. Lamins, including LA, LB1, LB2, and LC, are the major protein components forming the nuclear lamina to support the mechanical stability of the mammalian cell nucleus. ...However, the mechanisms underlying thi …
Nuclear lamins are type V intermediate filament proteins. Lamins, including LA, LB1, LB2, and LC, are the major protein compon …
Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins.
Li BX, Chen J, Chao B, David LL, Xiao X. Li BX, et al. ACS Chem Biol. 2018 May 18;13(5):1380-1387. doi: 10.1021/acschembio.8b00266. Epub 2018 Apr 19. ACS Chem Biol. 2018. PMID: 29648791 Free PMC article.
Using extensive chemical, biochemical, and cellular studies with this probe and LBL1, we found that LBL1 targets nuclear lamins, which are type V intermediate filament (IF) proteins. Further studies showed that LBL1 binds to the coiled-coil domain of lamin A. These …
Using extensive chemical, biochemical, and cellular studies with this probe and LBL1, we found that LBL1 targets nuclear lamins, whic …
Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy.
Méjat A, Decostre V, Li J, Renou L, Kesari A, Hantaï D, Stewart CL, Xiao X, Hoffman E, Bonne G, Misteli T. Méjat A, et al. J Cell Biol. 2009 Jan 12;184(1):31-44. doi: 10.1083/jcb.200811035. Epub 2009 Jan 5. J Cell Biol. 2009. PMID: 19124654 Free PMC article.
The LMNA gene encodes lamins A and C, two intermediate filament-type proteins that are important determinants of interphase nuclear architecture. ...AD-EDMD patients with LMNA mutations show the same cellular defects as the AD-EDMD mouse models. These results suggest that …
The LMNA gene encodes lamins A and C, two intermediate filament-type proteins that are important determinants of interphase nuclear a …
The Clinical Characteristics and Potential Molecular Mechanism of LMNA Mutation-Related Lipodystrophy.
Xiao C, Liu J, Yang C, Zhai X, Liu P, Xiao X, Yu M. Xiao C, et al. Adv Biol (Weinh). 2023 Sep;7(9):e2200301. doi: 10.1002/adbi.202200301. Epub 2023 Jun 11. Adv Biol (Weinh). 2023. PMID: 37303127
Protein stability, degradation pathways, and binding proteins of mutant Lamin A/C are examined using Western blotting, co-immunoprecipitation, and mass spectrometry. ...It is found to decreased mutant Lamin A/C stability and degradation primarily through the UPS, of …
Protein stability, degradation pathways, and binding proteins of mutant Lamin A/C are examined using Western blotting, co-immunopreci …
32 results