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The Role of Translocator Protein TSPO in Hallmarks of Glioblastoma.
Ammer LM, Vollmann-Zwerenz A, Ruf V, Wetzel CH, Riemenschneider MJ, Albert NL, Beckhove P, Hau P. Ammer LM, et al. Cancers (Basel). 2020 Oct 14;12(10):2973. doi: 10.3390/cancers12102973. Cancers (Basel). 2020. PMID: 33066460 Free PMC article. Review.
Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages.
Weidner L, Lorenz J, Quach S, Braun FK, Rothhammer-Hampl T, Ammer LM, Vollmann-Zwerenz A, Bartos LM, Dekorsy FJ, Holzgreve A, Kirchleitner SV, Thon N, Greve T, Ruf V, Herms J, Bader S, Milenkovic VM, von Baumgarten L, Menevse AN, Hussein A, Sax J, Wetzel CH, Rupprecht R, Proescholdt M, Schmidt NO, Beckhove P, Hau P, Tonn JC, Bartenstein P, Brendel M, Albert NL, Riemenschneider MJ. Weidner L, et al. Among authors: ammer lm. Acta Neuropathol Commun. 2023 Sep 11;11(1):147. doi: 10.1186/s40478-023-01651-5. Acta Neuropathol Commun. 2023. PMID: 37697350 Free PMC article.
TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma.
Menevse AN, Ammer LM, Vollmann-Zwerenz A, Kupczyk M, Lorenz J, Weidner L, Hussein A, Sax J, Mühlbauer J, Heuschneider N, Rohrmus C, Mai LS, Jachnik B, Stamova S, Volpin V, Durst FC, Sorrentino A, Xydia M, Milenkovic VM, Bader S, Braun FK, Wetzel C, Albert NL, Tonn JC, Bartenstein P, Proescholdt M, Schmidt NO, Linker RA, Riemenschneider MJ, Beckhove P, Hau P. Menevse AN, et al. Among authors: ammer lm. Acta Neuropathol Commun. 2023 May 8;11(1):75. doi: 10.1186/s40478-023-01550-9. Acta Neuropathol Commun. 2023. PMID: 37158962 Free PMC article.