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Identification of potential therapeutic targets in hypertension-associated bladder dysfunction.
Yono M, Yoshida M, Yamamoto Y, Imanishi A, Fukagawa A, Latifpour J, Eto M. Yono M, et al. BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18. BJU Int. 2010. PMID: 19689474
OBJECTIVE: To investigate differential gene expression profiles in the bladder of spontaneously hypertensive rat (SHR), as the underlying mechanisms involved in hypertension-associated bladder dysfunction remain to be clarified. MATERIALS AND METHODS: SHR and normotensive Wistar- …
OBJECTIVE: To investigate differential gene expression profiles in the bladder of spontaneously hypertensive rat (SHR), as the underlying me …
Effects of age and hypertension on α1-adrenoceptors in the major source arteries of the rat bladder and penis.
Yono M, Tanaka T, Tsuji S, Irie S, Sakata Y, Otani M, Yoshida M, Latifpour J. Yono M, et al. Eur J Pharmacol. 2011 Nov 16;670(1):260-5. doi: 10.1016/j.ejphar.2011.08.010. Epub 2011 Sep 2. Eur J Pharmacol. 2011. PMID: 21910985
Using radioligand receptor binding, real-time reverse transcription-polymerase chain reaction (RT-PCR) and fluorescent microsphere infusion techniques, we compared 3 and 22-month-old male Fischer rats, and male normotensive Wistar-Kyoto (WKY) rats and spontaneously hyperte …
Using radioligand receptor binding, real-time reverse transcription-polymerase chain reaction (RT-PCR) and fluorescent microsphere infusion …
A comparison of the expression and contractile function of α1-adrenoceptors in seminal vesicle and vas deferens from normotensive and hypertensive rats.
Yono M, Tanaka T, Tsuji S, Hori M, Irie S, Sakata Y, Otani M, Yoshida M, Latifpour J. Yono M, et al. Eur J Pharmacol. 2012 Nov 5;694(1-3):104-10. doi: 10.1016/j.ejphar.2012.08.005. Epub 2012 Aug 31. Eur J Pharmacol. 2012. PMID: 22960063
Spontaneous seminal emission in male spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats was studied during the 3-day observation period. ...
Spontaneous seminal emission in male spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats was studied duri …
Molecular mechanisms regulating urogenital expression of nitric oxide synthase in spontaneously hypertensive rats.
Yono M, Yoshida M, Yamamoto Y, Imanishi A, Fukagawa A, Latifpour J, Eto M. Yono M, et al. Life Sci. 2009 Aug 12;85(7-8):334-8. doi: 10.1016/j.lfs.2009.06.014. Epub 2009 Jul 2. Life Sci. 2009. PMID: 19576905
Therefore, we identified differential gene expression profiles in SHRs to elucidate the molecular mechanisms regulating urogenital expression of NOS. MAIN METHODS: SHRs and normotensive Wistar-Kyoto (WKY) rats received doxazosin (30 mg/kg/day) or nifedipine (30 mg/kg/day) …
Therefore, we identified differential gene expression profiles in SHRs to elucidate the molecular mechanisms regulating urogenital expressio …
Differential effects of prazosin and naftopidil on pelvic blood flow and nitric oxide synthase levels in spontaneously hypertensive rats.
Yono M, Yamamoto Y, Imanishi A, Yoshida M, Ueda S, Latifpour J. Yono M, et al. J Recept Signal Transduct Res. 2008;28(4):403-12. doi: 10.1080/10799890802176626. J Recept Signal Transduct Res. 2008. PMID: 18702011
We compared the effects of two alpha(1)-adrenoceptor antagonists with different selectivity for the alpha(1)-adrenoceptor subtypes, prazosin and naftopidil, on pelvic blood flow and nitric oxide synthase (NOS) levels in the spontaneously hypertensive rat (SHR). SHRs and normotens …
We compared the effects of two alpha(1)-adrenoceptor antagonists with different selectivity for the alpha(1)-adrenoceptor subtypes, prazosin …
Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract.
Yono M, Yamamoto Y, Yoshida M, Ueda S, Latifpour J. Yono M, et al. Life Sci. 2007 Jun 27;81(3):218-22. doi: 10.1016/j.lfs.2007.05.004. Epub 2007 May 21. Life Sci. 2007. PMID: 17574276 Free PMC article.
Four groups of rats were assessed: group 1, SHRs treated with doxazosin (30 mg/kg/day) for 4 weeks; group 2, SHRs treated with nifedipine (30 mg/kg/day) for 4 weeks; group 3, untreated SHRs; and group 4, untreated Wistar-Kyoto (WKY) rats. Blood flow to the ventral prostate …
Four groups of rats were assessed: group 1, SHRs treated with doxazosin (30 mg/kg/day) for 4 weeks; group 2, SHRs treated with nifedipine (3 …