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Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
Mejdrová I, Dušek J, Škach K, Stefela A, Skoda J, Chalupský K, Dohnalová K, Pavkova I, Kronenberger T, Rashidian A, Smutná L, Duchoslav V, Smutny T, Pávek P, Nencka R. Mejdrová I, et al. Among authors: skach k. J Med Chem. 2023 Feb 23;66(4):2422-2456. doi: 10.1021/acs.jmedchem.2c01140. Epub 2023 Feb 9. J Med Chem. 2023. PMID: 36756805 Free PMC article.
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Břehová P, Řezníčková E, Škach K, Jorda R, Dejmek M, Vojáčková V, Šála M, Kovalová M, Dračínský M, Dolníková A, Strmeň T, Kinnertová M, Chalupský K, Dvořáková A, Gucký T, Mertlíková Kaiserová H, Klener P, Nencka R, Kryštof V. Břehová P, et al. Among authors: skach k. J Med Chem. 2023 Aug 24;66(16):11133-11157. doi: 10.1021/acs.jmedchem.3c00575. Epub 2023 Aug 3. J Med Chem. 2023. PMID: 37535845 Free PMC article.
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.
Misehe M, Matoušová M, Dvořáková A, Hercík K, Škach K, Chalupská D, Dejmek M, Šála M, Hájek M, Boura E, Mertlíková-Kaiserová H, Nencka R. Misehe M, et al. Among authors: skach k. Eur J Med Chem. 2023 Nov 15;260:115717. doi: 10.1016/j.ejmech.2023.115717. Epub 2023 Aug 9. Eur J Med Chem. 2023. PMID: 37598483 Free article.