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Page 1
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
J Med Chem. 2023 Feb 23;66(4):2422-2456. doi: 10.1021/acs.jmedchem.2c01140. Epub 2023 Feb 9.
J Med Chem. 2023.
PMID: 36756805
Free PMC article.
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Břehová P, Řezníčková E, Škach K, Jorda R, Dejmek M, Vojáčková V, Šála M, Kovalová M, Dračínský M, Dolníková A, Strmeň T, Kinnertová M, Chalupský K, Dvořáková A, Gucký T, Mertlíková Kaiserová H, Klener P, Nencka R, Kryštof V.
Břehová P, et al. Among authors: skach k.
J Med Chem. 2023 Aug 24;66(16):11133-11157. doi: 10.1021/acs.jmedchem.3c00575. Epub 2023 Aug 3.
J Med Chem. 2023.
PMID: 37535845
Free PMC article.
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PF74 and Its Novel Derivatives Stabilize Hexameric Lattice of HIV-1 Mature-Like Particles.
Dostálková A, Škach K, Kaufman F, Křížová I, Hadravová R, Flegel M, Ruml T, Hrabal R, Rumlová M.
Dostálková A, et al. Among authors: skach k.
Molecules. 2020 Apr 20;25(8):1895. doi: 10.3390/molecules25081895.
Molecules. 2020.
PMID: 32325987
Free PMC article.
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Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.
Misehe M, Matoušová M, Dvořáková A, Hercík K, Škach K, Chalupská D, Dejmek M, Šála M, Hájek M, Boura E, Mertlíková-Kaiserová H, Nencka R.
Misehe M, et al. Among authors: skach k.
Eur J Med Chem. 2023 Nov 15;260:115717. doi: 10.1016/j.ejmech.2023.115717. Epub 2023 Aug 9.
Eur J Med Chem. 2023.
PMID: 37598483
Free article.
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A simple, high-throughput stabilization assay to test HIV-1 uncoating inhibitors.
Dostálková A, Hadravová R, Kaufman F, Křížová I, Škach K, Flegel M, Hrabal R, Ruml T, Rumlová M.
Dostálková A, et al. Among authors: skach k.
Sci Rep. 2019 Nov 19;9(1):17076. doi: 10.1038/s41598-019-53483-w.
Sci Rep. 2019.
PMID: 31745222
Free PMC article.
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