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Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.
Zakharova O, Luzina O, Zakharenko A, Sokolov D, Filimonov A, Dyrkheeva N, Chepanova A, Ilina E, Ilyina A, Klabenkova K, Chelobanov B, Stetsenko D, Zafar A, Eurtivong C, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O. Zakharova O, et al. Among authors: klabenkova k. Bioorg Med Chem. 2018 Aug 15;26(15):4470-4480. doi: 10.1016/j.bmc.2018.07.039. Epub 2018 Jul 24. Bioorg Med Chem. 2018. PMID: 30076000
New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.
Dyrkheeva NS, Filimonov AS, Luzina OA, Orlova KA, Chernyshova IA, Kornienko TE, Malakhova AA, Medvedev SP, Zakharenko AL, Ilina ES, Anarbaev RO, Naumenko KN, Klabenkova KV, Burakova EA, Stetsenko DA, Zakian SM, Salakhutdinov NF, Lavrik OI. Dyrkheeva NS, et al. Among authors: klabenkova kv. Int J Mol Sci. 2021 Oct 20;22(21):11336. doi: 10.3390/ijms222111336. Int J Mol Sci. 2021. PMID: 34768766 Free PMC article.