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Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats.
O'Hare M, Esquiva G, McGahon MK, Hombrebueno JMR, Augustine J, Canning P, Edgar KS, Barabas P, Friedel T, Cincolà P, Henry J, Mayne K, Ferrin H, Stitt AW, Lyons TJ, Brazil DP, Grieve DJ, McGeown JG, Curtis TM. O'Hare M, et al. Among authors: edgar ks. JCI Insight. 2022 Sep 22;7(18):e155128. doi: 10.1172/jci.insight.155128. JCI Insight. 2022. PMID: 36134661 Free PMC article.
ECSIT is a critical limiting factor for cardiac function.
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar KS, Hombrebueno JR, Stolz DB, Oleszycka E, Rodgers AM, Glezeva N, McDonald K, Watson CJ, Ledwidge MT, Ingram RJ, Grieve DJ, Moynagh PN. Xu L, et al. Among authors: edgar ks. JCI Insight. 2021 Jun 22;6(12):e142801. doi: 10.1172/jci.insight.142801. JCI Insight. 2021. PMID: 34032637 Free PMC article.
Spatial Gene Expression Changes in the Mouse Heart After Base-Targeted Irradiation.
Walls GM, Ghita M, Queen R, Edgar KS, Gill EK, Kuburas R, Grieve DJ, Watson CJ, McWilliam A, Van Herk M, Williams KJ, Cole AJ, Jain S, Butterworth KT. Walls GM, et al. Among authors: edgar ks. Int J Radiat Oncol Biol Phys. 2023 Feb 1;115(2):453-463. doi: 10.1016/j.ijrobp.2022.08.031. Epub 2022 Aug 17. Int J Radiat Oncol Biol Phys. 2023. PMID: 35985456 Free article.
Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart.
Ghita M, Gill EK, Walls GM, Edgar KS, McMahon SJ, Osorio EV, Bergom C, Grieve DJ, Watson CJ, McWilliam A, Aznar M, van Herk M, Williams KJ, Butterworth KT. Ghita M, et al. Among authors: edgar ks. Radiother Oncol. 2020 Nov;152:216-221. doi: 10.1016/j.radonc.2020.07.016. Epub 2020 Jul 12. Radiother Oncol. 2020. PMID: 32663535 Free PMC article.
PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia.
Pun SH, O'Neill KM, Edgar KS, Gill EK, Moez A, Naderi-Meshkin H, Malla SB, Hookham MB, Alsaggaf M, Madishetti VV, Botezatu B, King W, Brunssen C, Morawietz H, Dunne PD, Brazil DP, Medina RJ, Watson CJ, Grieve DJ. Pun SH, et al. Among authors: edgar ks. Cells. 2023 Sep 6;12(18):2220. doi: 10.3390/cells12182220. Cells. 2023. PMID: 37759443 Free PMC article.
NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes post-ischaemic revascularization.
O'Neill KM, Campbell DC, Edgar KS, Gill EK, Moez A, McLoughlin KJ, O'Neill CL, Dellett M, Hargey CJ, Abudalo RA, O'Hare M, Doyle P, Toh T, Khoo J, Wong J, McCrudden CM, Meloni M, Brunssen C, Morawietz H, Yoder MC, McDonald DM, Watson CJ, Stitt AW, Margariti A, Medina RJ, Grieve DJ. O'Neill KM, et al. Among authors: edgar ks. Cardiovasc Res. 2020 Feb 1;116(2):393-405. doi: 10.1093/cvr/cvz090. Cardiovasc Res. 2020. PMID: 30937452
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