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Page 1
Showing results for kevin coupling
Search for Kevin Couling instead (1 results)
Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues.
Limone F, Guerra San Juan I, Mitchell JM, Smith JLM, Raghunathan K, Meyer D, Ghosh SD, Couto A, Klim JR, Joseph BJ, Gold J, Mello CJ, Nemesh J, Smith BM, Verhage M, McCarroll SA, Pietiläinen O, Nehme R, Eggan K. Limone F, et al. Cell Rep. 2023 Jan 31;42(1):111896. doi: 10.1016/j.celrep.2022.111896. Epub 2023 Jan 2. Cell Rep. 2023. PMID: 36596304 Free PMC article.
Current protocols either direct neuronal differentiation with small molecules or use transcription-factor-mediated programming. In this study, we couple overexpression of transcription factor Neurogenin2 (Ngn2) with small molecule patterning to differentiate hPSCs into low …
Current protocols either direct neuronal differentiation with small molecules or use transcription-factor-mediated programming. In this stud …
Prescription of Controlled Substances: Benefits and Risks.
Preuss CV, Kalava A, King KC. Preuss CV, et al. 2023 Apr 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Apr 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30726003 Free Books & Documents.
Please note that the Drug Enforcement Administration (DEA, USA) uses the term "narcotic" to refer to drugs that are opioid analgesics. Five Characteristics of Addiction/Use Disorder (ASAM): 1. Craving for drug or reward. 2. ...A patient abusing an opioid analgesic may no l …
Please note that the Drug Enforcement Administration (DEA, USA) uses the term "narcotic" to refer to drugs that are opioid analgesics. Five …
Analysis of patients without and with an initial triple-negative breast cancer diagnosis in the phase 3 randomized ASCENT study of sacituzumab govitecan in metastatic triple-negative breast cancer.
O'Shaughnessy J, Brufsky A, Rugo HS, Tolaney SM, Punie K, Sardesai S, Hamilton E, Loirat D, Traina T, Leon-Ferre R, Hurvitz SA, Kalinsky K, Bardia A, Henry S, Mayer I, Zhu Y, Phan S, Cortés J. O'Shaughnessy J, et al. Breast Cancer Res Treat. 2022 Sep;195(2):127-139. doi: 10.1007/s10549-022-06602-7. Epub 2022 May 11. Breast Cancer Res Treat. 2022. PMID: 35545724 Free PMC article. Clinical Trial.
PURPOSE: Sacituzumab govitecan (SG) is an antibody-drug conjugate composed of an anti-Trop-2 antibody coupled to SN-38 via a proprietary hydrolyzable linker. In the ASCENT study, SG improved survival versus single-agent treatment of physician's choice (TPC) in pre-treated …
PURPOSE: Sacituzumab govitecan (SG) is an antibody-drug conjugate composed of an anti-Trop-2 antibody coupled to SN-38 via a propriet …
Henry's Law.
Avishay DM, Tenny KM. Avishay DM, et al. 2023 Jan 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jan 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31335021 Free Books & Documents.
A subspecialty within occupational medicine, the challenge of aerospace medicine lies in safeguarding the health of individuals who work in a dynamic atmosphere of lowering pressure and oxygen content, coupled with increasing altitude. It is essential to comprehend the phy …
A subspecialty within occupational medicine, the challenge of aerospace medicine lies in safeguarding the health of individuals who work in …
Goal-Directed Therapy for Cardiac Surgery.
Lobdell KW, Chatterjee S, Sander M. Lobdell KW, et al. Crit Care Clin. 2020 Oct;36(4):653-662. doi: 10.1016/j.ccc.2020.06.004. Epub 2020 Aug 12. Crit Care Clin. 2020. PMID: 32892819 Review.
Goal-directed therapy couples therapeutic interventions with physiologic and metabolic targets to mitigate a patient's modifiable risks for death and complications. ...
Goal-directed therapy couples therapeutic interventions with physiologic and metabolic targets to mitigate a patient's modifiable ris …
M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments.
Kalia NP, Singh S, Hards K, Cheung CY, Sviriaeva E, Banaei-Esfahani A, Aebersold R, Berney M, Cook GM, Pethe K. Kalia NP, et al. Cell Rep. 2023 May 30;42(5):112444. doi: 10.1016/j.celrep.2023.112444. Epub 2023 Apr 26. Cell Rep. 2023. PMID: 37115669 Free article.
The capacity of mycobacteria to scavenge trace levels of oxygen, coupled with the absence of complex regulatory mechanisms to achieve hierarchal control of the terminal oxidases, may be a key determinant of long-term M. tuberculosis survival in hypoxic lung granulomas....
The capacity of mycobacteria to scavenge trace levels of oxygen, coupled with the absence of complex regulatory mechanisms to achieve …
Gas-phase infrared spectroscopy of glycans and glycoconjugates.
Greis K, Kirschbaum C, von Helden G, Pagel K. Greis K, et al. Curr Opin Struct Biol. 2022 Feb;72:194-202. doi: 10.1016/j.sbi.2021.11.006. Epub 2021 Dec 21. Curr Opin Struct Biol. 2022. PMID: 34952241 Review.
Standard workflows for glycan analysis are based on mass spectrometry, often coupled with separation techniques such as liquid chromatography and ion mobility spectrometry. ...
Standard workflows for glycan analysis are based on mass spectrometry, often coupled with separation techniques such as liquid chroma …
Advanced endoscopic technologies.
Reavis KM, Melvin WS. Reavis KM, et al. Surg Endosc. 2008 Jun;22(6):1533-46. doi: 10.1007/s00464-008-9831-1. Epub 2008 Apr 10. Surg Endosc. 2008. PMID: 18401657 Review.
Initially, endoscopy relied on rigid telescopes, direct visualization, and dangerously exothermic sources of illumination. The introduction of fiber optics, charge-coupled-device cameras, and increasingly efficient light sources has enabled researchers to investigate areas …
Initially, endoscopy relied on rigid telescopes, direct visualization, and dangerously exothermic sources of illumination. The introduction …
Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling.
Mayourian J, Ceholski DK, Gonzalez DM, Cashman TJ, Sahoo S, Hajjar RJ, Costa KD. Mayourian J, et al. Circ Res. 2018 Jan 5;122(1):167-183. doi: 10.1161/CIRCRESAHA.117.311589. Circ Res. 2018. PMID: 29301848 Free PMC article. Review.
Cardiac excitation-contraction coupling (ECC) is the orchestrated process of initial myocyte electrical excitation, which leads to calcium entry, intracellular trafficking, and subsequent sarcomere shortening and myofibrillar contraction. ...
Cardiac excitation-contraction coupling (ECC) is the orchestrated process of initial myocyte electrical excitation, which leads to ca …
Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis.
Lee BS, Pethe K. Lee BS, et al. Curr Opin Pharmacol. 2018 Oct;42:22-26. doi: 10.1016/j.coph.2018.06.006. Epub 2018 Jul 17. Curr Opin Pharmacol. 2018. PMID: 30015177 Review.
The dominance of these targets in cell-based screens reflect not only bias introduced by experimental setup, but also some of the pathogen's greatest vulnerabilities. Coupled with favourable predictions of their in vivo efficacies and synergism with other TB drugs, these t …
The dominance of these targets in cell-based screens reflect not only bias introduced by experimental setup, but also some of the pathogen's …
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