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Showing results for keto xu
Search for Ketao Xu instead (3 results)
Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression.
Qian L, Li N, Lu XC, Xu M, Liu Y, Li K, Zhang Y, Hu K, Qi YT, Yao J, Wu YL, Wen W, Huang S, Chen ZJ, Yin M, Lei QY. Qian L, et al. Nat Metab. 2023 Jul;5(7):1159-1173. doi: 10.1038/s42255-023-00818-7. Epub 2023 Jun 19. Nat Metab. 2023. PMID: 37337119
BCAT1 directly interacts with RhoC, leading to elevation of RhoC activity. Notably, the BCAA-derived metabolite, branched-chain alpha-keto acid directly binds to the small GTPase protein RhoC and promotes its activity. BCAT1 knockout-suppressed cell motility could be rescu …
BCAT1 directly interacts with RhoC, leading to elevation of RhoC activity. Notably, the BCAA-derived metabolite, branched-chain alpha-ket
Ketogenic Diet as a Promising Non-Drug Intervention for Alzheimer's Disease: Mechanisms and Clinical Implications.
Xu Y, Zheng F, Zhong Q, Zhu Y. Xu Y, et al. J Alzheimers Dis. 2023;92(4):1173-1198. doi: 10.3233/JAD-230002. J Alzheimers Dis. 2023. PMID: 37038820 Review.
However, dietary interventions may be a potential strategy to treat AD. The ketogenic diet (KD) is a high-fat and low-carbohydrate diet with adequate protein. ...
However, dietary interventions may be a potential strategy to treat AD. The ketogenic diet (KD) is a high-fat and low-carbohyd …
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis.
Xu S, Tao H, Cao W, Cao L, Lin Y, Zhao SM, Xu W, Cao J, Zhao JY. Xu S, et al. Signal Transduct Target Ther. 2021 Feb 9;6(1):54. doi: 10.1038/s41392-020-00411-4. Signal Transduct Target Ther. 2021. PMID: 33558457 Free PMC article.
In addition to their use in relieving the symptoms of various diseases, ketogenic diets (KDs) have also been adopted by healthy individuals to prevent being overweight. ...
In addition to their use in relieving the symptoms of various diseases, ketogenic diets (KDs) have also been adopted by healthy indiv …
The effect of periodic ketogenic diet on newly diagnosed overweight or obese patients with type 2 diabetes.
Li S, Lin G, Chen J, Chen Z, Xu F, Zhu F, Zhang J, Yuan S. Li S, et al. BMC Endocr Disord. 2022 Feb 3;22(1):34. doi: 10.1186/s12902-022-00947-2. BMC Endocr Disord. 2022. PMID: 35115003 Free PMC article. Clinical Trial.
BACKGROUND: The ketogenic diet (KD) is characterized by fat as a substitute of carbohydrates for the primary energy source. ...METHODS: A total of 60 overweight or obese patients newly diagnosed as T2DM were randomized into two groups: KD group, which was given k
BACKGROUND: The ketogenic diet (KD) is characterized by fat as a substitute of carbohydrates for the primary energy source. .. …
Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability.
Zhang H, Zheng Q, Guo T, Zhang S, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang XF, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang CS, Xu H, Wang X. Zhang H, et al. Mol Psychiatry. 2022 Mar 25. doi: 10.1038/s41380-022-01521-x. Online ahead of print. Mol Psychiatry. 2022. PMID: 35338313
SNX27(R196W) resulted in attenuated astrocytic glucose uptake via GLUT1, leading to reduced lactate production and a switch from homeostatic to reactive astrocytes. Importantly, lactate supplementation or a ketogenic diet restored neuronal oxidative phosphorylation …
SNX27(R196W) resulted in attenuated astrocytic glucose uptake via GLUT1, leading to reduced lactate production and a switch from homeostatic …
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade.
Dai X, Bu X, Gao Y, Guo J, Hu J, Jiang C, Zhang Z, Xu K, Duan J, He S, Zhang J, Wan L, Liu T, Zhou X, Hung MC, Freeman GJ, Wei W. Dai X, et al. Mol Cell. 2021 Jun 3;81(11):2317-2331.e6. doi: 10.1016/j.molcel.2021.03.037. Epub 2021 Apr 27. Mol Cell. 2021. PMID: 33909988 Free PMC article.
Aberrant energy status contributes to multiple metabolic diseases, including obesity, diabetes, and cancer, but the underlying mechanism remains elusive. Here, we report that ketogenic-diet-induced changes in energy status enhance the efficacy of anti-CTLA-4 immunot …
Aberrant energy status contributes to multiple metabolic diseases, including obesity, diabetes, and cancer, but the underlying mechanism rem …
AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy.
Wu C, Dai C, Li X, Sun M, Chu H, Xuan Q, Yin Y, Fang C, Yang F, Jiang Z, Lv Q, He K, Qu Y, Zhao B, Cai K, Zhang S, Sun R, Xu G, Zhang L, Sun S, Liu Y. Wu C, et al. Theranostics. 2022 Nov 7;12(18):7681-7698. doi: 10.7150/thno.74974. eCollection 2022. Theranostics. 2022. PMID: 36451864 Free PMC article.
Using multi-omics analysis in cultured HCC cells, we identified that aldo-keto reductase AKR1C3 is responsible for LD accumulation in HCC. ...
Using multi-omics analysis in cultured HCC cells, we identified that aldo-keto reductase AKR1C3 is responsible for LD accumulation in …
Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD.
Cao H, Cai Q, Guo W, Su Q, Qin H, Wang T, Xian Y, Zeng L, Cai M, Guan H, Chen S, Liang H, Xu F. Cao H, et al. Cell Rep. 2023 Apr 25;42(4):112319. doi: 10.1016/j.celrep.2023.112319. Epub 2023 Mar 31. Cell Rep. 2023. PMID: 37002924 Free article.
Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here, we investigate the involvement of PTMs in ketogenic diet (KD …
Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the …
Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer's disease.
Xu Y, Jiang C, Wu J, Liu P, Deng X, Zhang Y, Peng B, Zhu Y. Xu Y, et al. CNS Neurosci Ther. 2022 Apr;28(4):580-592. doi: 10.1111/cns.13779. Epub 2021 Dec 10. CNS Neurosci Ther. 2022. PMID: 34889516 Free PMC article.
The positive effect of ketogenic diet on cognitive functions depended on the starting time and the duration of the diet. A shorter period (2 months) of ketogenic diet treatment had a weaker effect. Ketogenic diet initiated at late …
The positive effect of ketogenic diet on cognitive functions depended on the starting time and the duration of the diet
1,5-Dimethyl-4-(1-methyl-3-oxo-3-phenylprop-1-enyl-amino)-2-phenyl-1H-pyrazol-3(2H)-one.
Zhu H, Wang Z, Ren J, Zhang M, Xu W. Zhu H, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):o1640. doi: 10.1107/S1600536811021945. Epub 2011 Jun 11. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 21837045 Free PMC article.
In the title compound, C(21)H(21)N(3)O(2), an intra-molecular N-HO inter-action generates an S(6) ring, which stablizes the enamine-keto tautomer. The S(6) ring makes dihedral angles of 33.07 (7), 56.50 (8) and 38.59 (8), respectively, with the benzoyl-acetone benzene ring …
In the title compound, C(21)H(21)N(3)O(2), an intra-molecular N-HO inter-action generates an S(6) ring, which stablizes the enamine-keto
572 results