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Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism.
Kurniawan DA, Leo S, Inamatsu M, Funaoka S, Aihara T, Aiko M, Rei I, Sakura T, Arakawa H, Kato Y, Matsugi T, Esashika K, Shiraki N, Kume S, Shinha K, Kimura H, Nishikawa M, Sakai Y. Kurniawan DA, et al. Among authors: shinha k. PNAS Nexus. 2024 Feb 9;3(2):pgae070. doi: 10.1093/pnasnexus/pgae070. eCollection 2024 Feb. PNAS Nexus. 2024. PMID: 38384383 Free PMC article.
Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system.
Shinohara M, Arakawa H, Oda Y, Shiraki N, Sugiura S, Nishiuchi T, Satoh T, Iino K, Leo S, Kato Y, Araya K, Kawanishi T, Nakatsuji T, Mitsuta M, Inamura K, Goto T, Shinha K, Nihei W, Komori K, Nishikawa M, Kume S, Kato Y, Kanamori T, Sakai Y, Kimura H. Shinohara M, et al. Among authors: shinha k. Sci Rep. 2021 Mar 8;11(1):5437. doi: 10.1038/s41598-021-84861-y. Sci Rep. 2021. PMID: 33686099 Free PMC article.