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A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases.
Samrat SK, Bashir Q, Zhang R, Huang Y, Liu Y, Wu X, Brown T, Wang W, Zheng YG, Zhang QY, Chen Y, Li Z, Li H. Samrat SK, et al. Emerg Microbes Infect. 2023 Dec;12(1):2204164. doi: 10.1080/22221751.2023.2204164. Emerg Microbes Infect. 2023. PMID: 37060263 Free PMC article.
In this study, we report a universal fluorescence polarization (FP)-based high throughput screening (HTS) assay for SAM-dependent viral methyltransferases (MTases), using a fluorescent SAM-analogue, FL-NAH. We performed the assay against a reference MTase, NSP14, an essent …
In this study, we report a universal fluorescence polarization (FP)-based high throughput screening (HTS) assay for SAM-dependent viral meth …
Broad-Spectrum Small-Molecule Inhibitors Targeting the SAM-Binding Site of Flavivirus NS5 Methyltransferase.
Samrat SK, Bashir Q, Huang Y, Trieshmann CW, Tharappel AM, Zhang R, Chen K, Zheng YG, Li Z, Li H. Samrat SK, et al. ACS Infect Dis. 2023 Jul 14;9(7):1319-1333. doi: 10.1021/acsinfecdis.2c00571. Epub 2023 Jun 22. ACS Infect Dis. 2023. PMID: 37348028
The NS5 protein is regarded as one of the most promising flavivirus drug targets because it is conserved across flaviviruses. In this study, we used FL-NAH, a fluorescent analog of the methyl donor S-adenosyl methionine (SAM), to develop a fluorescence polarization (FP)-ba …
The NS5 protein is regarded as one of the most promising flavivirus drug targets because it is conserved across flaviviruses. In this study, …
Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography.
Tanaka E, Nakamura T, Terada M, Shinozuka T, Hashimoto C, Kurihara K, Honda K. Tanaka E, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1;854(1-2):116-20. doi: 10.1016/j.jchromb.2007.04.004. Epub 2007 Apr 13. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17459789
., particle size 5 microm, Inersil ODS-SP). The mobile phase, consisting of acetonitrile-methanol-30 mM NaH(2)PO(4) (pH 5.6) (300:200:500, v/v/v), was delivered at a flow rate of 0.9 mL/min and UV detection was carried out at 250 nm. ...
., particle size 5 microm, Inersil ODS-SP). The mobile phase, consisting of acetonitrile-methanol-30 mM NaH(2)PO(4) (pH 5.6) (300:200 …
Simultaneous determination of three local anesthetic drugs from the pipecoloxylidide group in human serum by high-performance liquid chromatography.
Tanaka E, Nakamura T, Inomata S, Honda K. Tanaka E, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Apr 13;834(1-2):213-6. doi: 10.1016/j.jchromb.2006.02.034. Epub 2006 Mar 9. J Chromatogr B Analyt Technol Biomed Life Sci. 2006. PMID: 16530026
A high-performance liquid chromatographic (HPLC) method has been developed for the simultaneous analysis of the local anesthetic amide drugs, bupivacaine, mepivacaine and ropivacaine, belonging to the pipecoloxylidide group using a C(18) reversed-phase column (150 x 4.6 mm I.D.) …
A high-performance liquid chromatographic (HPLC) method has been developed for the simultaneous analysis of the local anesthetic amide drugs …