Abstract
Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat African river blindness and African sleeping sickness. Suramin has also been extensively trialed recently to treat a number of other diseases, including many cancers. Here, we examine its modes of action and discuss its structure-activity relationships.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use*
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Humans
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Neoplasms / drug therapy
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Onchocerciasis / drug therapy
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Onchocerciasis / parasitology
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Structure-Activity Relationship
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Suramin / chemistry
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Suramin / pharmacology*
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Suramin / therapeutic use*
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Suramin / toxicity
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Trypanocidal Agents / chemistry
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Trypanocidal Agents / pharmacology*
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Trypanocidal Agents / therapeutic use*
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Trypanosomiasis / drug therapy
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Trypanosomiasis / parasitology
Substances
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Antineoplastic Agents
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Trypanocidal Agents
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Suramin